Tudor tells about new twists in the story tale of SMURFs

M Z Qureshi; S Jabeen; G Butt; A Aslam; S K Naqvi; R Attar; S Tabassum; M Nasir; A A Farooqi

Issue

Vol. 62 No. 5: Recent advancements in molecular pathogenesis

Issue Published : April 30, 2016

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Tudor tells about new twists in the story tale of SMURFs

M Z Qureshi

GCU Department of Chemistry Lahore Pakistan

S Jabeen

PMAS-Arid Agriculture University Department of Zoology Rawalpindi Pakistan

G Butt

GCU Department of Botany Lahore Pakistan

A Aslam

QAU Faculty of Biological Sciences, Department of Microbiology Islamabad Pakistan

S K Naqvi

COMSATS Institute of Information Technology Islamabad Pakistan

R Attar

Yeditepe University School of Medicine Department of Obstetrics and Gynecology ć°stanbul Turkey

S Tabassum

International Islamic University Department of Bioinformatics and Biotechnology Islamabad Pakistan

M Nasir

Fatima Memorial College of Medicine and Dentistry Lahore Pakistan

A A Farooqi

RLMC Laboratory For Translational Oncology and Personalized Medicine Lahore Pakistan

Corresponding Author(s) : M Z Qureshi

Cellular and Molecular Biology, Vol. 62 No. 5: Recent advancements in molecular pathogenesis
Article Published : April 30, 2016

Abstract

Smad ubiquitin regulatory factors (SMURFS) belong to the HECT- family of E3 ubiquitin ligases. This family has two members, SMURF1 and SMURF2. SMURFs have emerged as well studied negative regulators of TGF induced intracellular signaling. However, increasingly it is being realized that SMURFs tactfully modulate an array of proteins in different cancers. This review sets spotlight on how SMURF1 and SMURF2 communicate with effectors of different signaling pathways during the multistep progression to cancer. We also summarize how microRNAs (miRNAs) effectively control SMURFs in different cancers. Role of SMURFs is context dependent in different cancers and better concepts related to miRNA regulation of SMURFs in different stages and steps of cancer will be helpful in efficient translation of laboratory findings to clinic.

Keywords

Cancer apoptosis signaling SMURF therapy.

Qureshi, M. Z., Jabeen, S., Butt, G., Aslam, A., Naqvi, S. K., Attar, R., Tabassum, S., Nasir, M., & Farooqi, A. A. (2016). Tudor tells about new twists in the story tale of SMURFs. Cellular and Molecular Biology, 62(5), 38–43. Retrieved from https://cellmolbiol.org/index.php/CMB/article/view/859