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Copyright (c) 2023 Xianfeng Wang, Qiaohong Lv, Zhangge Meng
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Analysis of the Related Influencing Factors of Hepatic Abscess Associated with Hepatobiliary Ischemic Necrosis after Cholangiocarcinoma Operation
Corresponding Author(s) : Zhangge Meng
Cellular and Molecular Biology,
Vol. 69 No. 5: Issue 5
Abstract
To investigate related factors of liver abscess associated with hepatobiliary ischemic necrosis after cholangiocarcinoma surgery, 100 patients with cholangiocarcinoma requiring surgical resection were collected and divided into a test group (53 patients with liver abscess) and a control group (47 patients without liver abscess) according to presence or absence of liver abscess. Related factors were compared: gender, age, body mass index (BMI), body temperature at admission, duration of medical history, presence or absence of a history of diabetes, time of medical history, presence or absence of hepatolithiasis, absolute neutrophil count, absolute lymphocyte count (ALC), C-reactive protein, serum albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), direct bilirubin (DBIL), serum creatine, and presence or absence of anemia. Univariate analysis showed that BMI, age, gender, absolute lymphocyte count, serum ALB, AST, and time of medical history were significantly different between the two (P<0.05). Multivariate logistic regression analysis of the above influencing factors showed that independent influencing factors of postoperative liver abscess formation were: ALC<1.1*10^9/L (P<0.001, OR=23.459, 95% CI=8.529-64.576), AST≥40 U/L (P=0.012, OR=3.946, 95% CI=1.355-11.487), time of medical history≥21 days (P=0.010, OR=4.028, 95% CI=1.389-11.681). Decreased ALC, increased AST, and occurrence of acute biliary tract infection were independent factors for hepatobiliary ischemic necrosis-related liver abscess. Abnormal nutritional status, age, and gender were also the influencing factors of liver abscess.
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