Jeong-Woong Park; Kyung Soo  Kang; In Su  Ha; Sang In Lee; Sangsu Shin

doi:10.14715/cmb/2023.69.2.2

Issue

Vol. 69 No. 2: Issue 2

Issue Published : May 24, 2023

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Efficacy of fucoxanthin extract from Sargassum horneri on 3T3-L1 pre-adipocyte differentiation

Effects of Fucoxanthin on 3T3-L1 differentiation.

https://doi.org/10.14715/cmb/2023.69.2.2

Jeong-Woong Park

Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Korea

Kyung Soo Kang

Department of Bio Life Sciences, Shingu College, Seongnam-si 13174, Korea

In Su Ha

Fucozen. Co., Ltd., Ansan-si, Gyeonggi-do 15577, Korea

Sang In Lee

Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Korea

https://orcid.org/0000-0002-0019-1834

Sangsu Shin

Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Korea

https://orcid.org/0000-0002-5264-9632

Corresponding Author(s) : Sangsu Shin

sss@knu.ac.kr

Cellular and Molecular Biology, Vol. 69 No. 2: Issue 2
Article Published : February 28, 2023

Abstract

Obesity, a chronic disease characterized by excessive body fat accumulation, is associated with significant health risks. The state of being overweight or obese leads to a number of chronic diseases, including cardiovascular disease, type 2 diabetes, cancer, and osteoarthritis. Accordingly, the regulation of adipocyte proliferation and differentiation has been the focus of many studies. The goal of the present study was to investigate the function of fucoxanthin, extracted from Sargassum horneri, in adipocyte (3T3-L1 cells) differentiation. A quantitative real-time polymerase chain reaction was conducted to investigate the mRNA expression levels of adipocyte differentiation-related genes under fucoxanthin stimulation. All adipocyte-related genes responded to PIC stimuli. Additionally, using western blotting, we confirmed that fucoxanthin reduced adipocyte differentiation. These results indicate that fucoxanthin extracted from Sargassum horneri can regulate adipogenesis. Further studies are needed to reveal the signaling pathways that lead to reduced adipocyte differentiation induced by fucoxanthin.

Keywords

Fucoxanthin 3T3-L1 Adipogenesis Sargassum horneri (TURNER) C. AGARDH Natural substances

Park, J.-W., Kang, K. S. ., Ha, I. S. ., Lee, S. I., & Shin, S. (2023). Efficacy of fucoxanthin extract from Sargassum horneri on 3T3-L1 pre-adipocyte differentiation: Effects of Fucoxanthin on 3T3-L1 differentiation. Cellular and Molecular Biology, 69(2), 8–11. https://doi.org/10.14715/cmb/2023.69.2.2