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Vol. 68 No. 9: Issue 9

Issue Published : March 11, 2023
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluating the effect of anti-nausea drugs in IDO enzyme gene expression and preventing postoperative vomiting and nausea in patients undergoing general anesthesia: A Meta-analysis

Anti-nausea drugs and preventing postoperative vomiting and nausea
https://doi.org/10.14715/cmb/2022.68.9.29
Yijian Chen
Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, Jiangxi341000, China
Shiwen Liu
Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, Jiangxi341000, China
Jiexian Liang
Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, Jiangxi341000, China
Hua Zhu
Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, Jiangxi341000, China

Corresponding Author(s) : Hua Zhu

y20212223jx@126.com

Cellular and Molecular Biology, Vol. 68 No. 9: Issue 9
Article Published : September 30, 2022

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Abstract

Nausea and vomiting are known as side effects after surgery. Since serotonin antagonist drugs are widely used to prevent nausea and vomiting after surgery, the present study was conducted to compare the effectiveness of this group's drugs, namely, ondansetron and palonosetron. On the other hand, recent studies have shown that the metabolites of the kynurenine pathway in the Suppression of the immune response play a role. Indoleamine 2,3 dioxygenase (IDO) is the main enzyme controlling this pathway. Therefore, the effect of these two drugs on IDO gene expression was evaluated. The present study is a systematic review with meta-analysis. The search was conducted in the Cochrane, PubMed, Clinical K, and CRD databases for randomized clinical trial articles that compared two drugs, palonosetron, and ondansetron, regarding nausea and vomiting in patients undergoing surgery with general anesthesia. In the end, eight studies were included in the meta-analysis. STATA13 statistical software was used to estimate the overall risk, relative risk, and data analysis. The results showed that the number of samples in all articles was 739. The analysis of the results between 0 and 24 hours showed that palonosetron reduces the incidence of nausea by 50% and the incidence of vomiting by 79% compared to ondansetron (p=0.001). Also, there was no difference between the IDO gene expression in the two drug groups (p>0.05). In general, the analysis of the results related to the effectiveness of palonosetron and ondansetron 24 hours after surgery with a dose of 0.075 mg of palonosetron versus 4 mg of ondansetron showed that palonosetron is more effective in reducing the incidence of nausea and vomiting in patients than ondansetron.

Keywords

Ondansetron Palonosetron Postoperative Nausea Vomiting General Anesthesia
Chen, Y., Liu, S., Liang, J., & Zhu, H. (2022). Evaluating the effect of anti-nausea drugs in IDO enzyme gene expression and preventing postoperative vomiting and nausea in patients undergoing general anesthesia: A Meta-analysis: Anti-nausea drugs and preventing postoperative vomiting and nausea. Cellular and Molecular Biology, 68(9), 186–191. https://doi.org/10.14715/cmb/2022.68.9.29
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