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Vol. 68 No. 6: Issue 6

Issue Published : October 7, 2022
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Protective Effect of Combined Moxibustion and Decoction Therapy on Bleomycin-Induced Pulmonary Fibrosis in Rats under Nuclear Factor-κB/Transforming Growth Factor-β1/Smads Signaling Pathway

Effects of Mox and BFQY on NF-κB and TGF-β1
https://doi.org/10.14715/cmb/2022.68.6.8
Shanjun Yang
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Xiao Feng
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Yue Wang
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Yang Qu
Department of Internal Medicine Clinic (a), Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Luming Xing
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Hao Wang
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Yujia Zhang
Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
Xiyao Li
First Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100007, China 1Department of Lung Disease, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China

Corresponding Author(s) : Yang Qu

tangnanzhan9579694@163.com

Cellular and Molecular Biology, Vol. 68 No. 6: Issue 6
Article Published : June 30, 2022

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Abstract

it was aimed to discuss the effect of moxibustion (Mox) combined with Bu Fei Qu Yu (BFQY) decoction under the nuclear factor-κB (NF-κB)/transforming growth factor-β1 (TGF-β1)/Smads signaling pathway in the treatment of pulmonary fibrosis (PF). The PF rat models were prepared with bleomycin (BLM). They were divided into the normal (Nor) group, the PF model group (BLM puncture perfusion), the Mox group (grain-sized Mox at the back-shu points and Xuxiao points), the BFQY group (intragastrical BFQY decoction), and the Mox combined with BFQY decoction (Mox+BFQY) group. Lung tissue sections were prepared, and the hematoxylin-eosin (HE) staining and Masson staining were performed to observe the inflammatory response and the degree of PF. The contents of hydroxyproline (HYP), glutathione (GSH), and malondialdehyde (MDA), and the expressions of NF-κB p65, TGF-β1, Smad2, and Smad7 in lung tissues were detected. Compared with those in the Nor group, the inflammatory response score, PF degree score, HYP, GSH, and MDA contents, NF-κB p65, TGF-β1, and Smad2 expressions were significantly increased in the PF group, but Smad7 expression decreased (P<0.05). The above symptoms were significantly improved in the Mox, BFQY, and Mox+ BFQY groups (P<0.05). The effect was more remarkable in the Mox+BFQY group, and there was no significant difference in each index compared with those in the Nor group (P>0.05). Thus, the combined therapy of Mox and decoction had an effect on PF through the NF-κB/TGF-β1/Smads pathway.

Keywords

bleomycin pulmonary fibrosis moxibustion Bu Fei Qu Yu decoction
Yang, S., Feng, X., Wang, Y., Qu, Y., Xing, L., Wang, H., Zhang, Y., & Li, X. (2022). Protective Effect of Combined Moxibustion and Decoction Therapy on Bleomycin-Induced Pulmonary Fibrosis in Rats under Nuclear Factor-κB/Transforming Growth Factor-β1/Smads Signaling Pathway: Effects of Mox and BFQY on NF-κB and TGF-β1. Cellular and Molecular Biology, 68(6), 48–55. https://doi.org/10.14715/cmb/2022.68.6.8
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