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Vol. 66 No. 5: Issue 5

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Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma

https://doi.org/10.14715/cmb/2020.66.5.31
Gang Xu
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Haosheng Zhang
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Zhibin Li
Materials and Interfaces Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China
Shihai Wu
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Rencui Quan
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Kun Mao
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Yang Sheng
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
Xianming Li
Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China

Corresponding Author(s) : Gang Xu

ujnt41@163.com

Cellular and Molecular Biology, Vol. 66 No. 5: Issue 5

Abstract

The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity. However, studies on the effect of gold nanomaterials carrying HIF-1αsiRNA on tumor radiotherapy, and the underlying mechanisms are limited. Thus, the present study was aimed at investigating the effect of gold nanocomposites (AuNRs) carrying HIF-1αsiRNA (AuNRs-HIF-1αsiRNA) on the radiation sensitivity of nasopharyngeal carcinoma (NPC) hypoxia cells. The effect of AuNRs-HIF-1αsiRNA on radiation sensitivity of hypoxic NPC cells was determined under X-ray irradiation. The results showed that Au-HIF-1αsiRNA improved the radio-sensitivity of NPC tumor. Thus, this study has demonstrated that gold nanomaterials carrying HIF-1αsiRNA effectively increased the radio-sensitivity of hypoxic tumor, thereby improving the effect of radiotherapy on NPC cells.

Keywords

uNRs HIF-1α siRNA Radiotherapy Sensitivity NPC Hypoxias.
Xu, G., Zhang, H., Li, Z., Wu, S., Quan, R., Mao, K., Sheng, Y., & Li, X. (2020). Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma. Cellular and Molecular Biology, 66(5), 185–190. https://doi.org/10.14715/cmb/2020.66.5.31
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