Cellular and Molecular Biology
by CMB Association
openjournathemelogo
Quick jump to page content
  • Main Navigation
  • Main Content
  • Sidebar
  • Home
  • About
    • About the Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Policies
    • Publication Ethics
    • Privacy Statement
    • Special Issue Proposal
    • Contact
  • Current
  • Archives
  • Call For Papers
  • Search
  1. Home
  2. Archives
  3. Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer
  4. Meta-Analysis

Issue

Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer

Issue Published : May 19, 2018

A meta-analysis of microRNA-17 as a potential biomarker in diagnosis of colorectal cancer

https://doi.org/10.14715/cmb/2018.64.6.15
Tao Liu
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin 130021, China
Libin Yin
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin 130021, China
Guoqiang Yan
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin 130021, China
Chao Li
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin 130021, China
Lei Wang
Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Jilin 130021, China

Corresponding Author(s) : Lei Wang

leiwang1967@163.com

Cellular and Molecular Biology, Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer
Article Published : May 15, 2018

Share
WA Share on Facebook Share on Twitter Pinterest Email Telegram
  • Abstract
  • Cite
  • References
  • Authors Details

Abstract

This meta-analysis was aimed to determine the diagnostic accuracy of circulating microRNA-17 for colorectal Cancer (CRC). Databases including PubMed, Embase, Web of Science, Cochrane Library and China National Knowledge Infrastructure (CNKI) were searched up to February 23, 2018 for eligible studies. Quality Assessment of Diagnostic Accuracy Studies (QUADAS) was employed to assess the quality of the included studies. Meta-analysis was performed in STATA 13.0. Ten studies with total 938 CRC patients and 638 control individuals were included in this meta-analysis. All of the included studies are of high quality. The summary estimates revealed that the pooled sensitivity is 0.75 (95% confidence interval (CI): 0.60–0.85) and the specificity is 68% (95% CI: 0.56–0.77), for the diagnosis of CRC. In addition, the area under the summary ROC curve (AUC) is 0.76. The current evidence suggests that circulating miR-17 has the potential diagnostic value for CRC. More prospective studies on the diagnostic value of circulating miR-17 for CRC are needed in the future. Together, microRNA-17 might be a novel potential biomarker in the diagnosis of colorectal cancer, and more studies are needed to highlight the theoretical strengths.

Keywords

MicroRNA-17 Colorectal cancer Diagnosis Meta-analysis.
Liu, T., Yin, L., Yan, G., Li, C., & Wang, L. (2018). A meta-analysis of microRNA-17 as a potential biomarker in diagnosis of colorectal cancer. Cellular and Molecular Biology, 64(6), 86–93. https://doi.org/10.14715/cmb/2018.64.6.15
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends”an update. Cancer Epidemiology and Prevention Biomarkers 2016; 25(1): 16-27.
  2. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. cell 2004; 116(2): 281-297.
  3. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nature reviews cancer 2006; 6(11): 857.
  4. Ng EK, Tsui NB, Lam NY et al. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clinical chemistry 2002; 48(8): 1212-1217.
  5. Silva J, Rodriguez R, Garcia J et al. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 2002; 50(4): 530-534.
  6. Barbarotto E, Schmittgen TD, Calin GA. MicroRNAs and cancer: profile, profile, profile. International journal of cancer 2008; 122(5): 969-977.
  7. Lanza G, Ferracin M, Gafí R et al. mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Molecular cancer 2007; 6(1): 54.
  8. Monzo M, Navarro A, Bandres E et al. Overlapping expression of microRNAs in human embryonic colon and colorectal cancer. Cell research 2008; 18(8): 823.
  9. Ayaz L, Görür A, Yaroğlu HY, í–zcan C, Tamer L. Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. Journal of cancer research and clinical oncology 2013; 139(9): 1499-1506.
  10. Humphreys KJ, McKinnon RA, Michael MZ. miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PloS one 2014; 9(11): e112288.
  11. Fang L, Li H, Wang L et al. MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. Oncotarget May 30 2014; 5(10): 2974-2987.
  12. Faltejskova P, Bocanek O, Sachlova M et al. Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: evidence against their usage as biomarkers in colorectal cancer. Cancer Biomarkers 2013; 12(4-5): 199-204.
  13. Whiting PF, Rutjes AW, Westwood ME et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Annals of internal medicine 2011; 155(8): 529-536.
  14. Fu F, Jiang W, Zhou L, Chen Z. Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer. Translational oncology 2018; 11(2): 221-232.
  15. Zekri A-RN, Youssef ASE-D, Lotfy MM et al. Circulating serum miRNAs as diagnostic markers for colorectal cancer. PLoS One 2016; 11(5): e0154130.
  16. Zhu J, Dong H, Zhang Q, Zhang S. Combined assays for serum carcinoembryonic antigen and microRNA"‘17-3p offer improved diagnostic potential for stage I/II colon cancer. Molecular and clinical oncology 2015; 3(6): 1315-1318.
  17. Zhang J, Raju GS, Chang DW, Lin SH, Chen Z, Wu X. Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer. Cancer 2018; 124(4): 785-796.
  18. Koga Y, Yasunaga M, Takahashi A et al. MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening. Cancer prevention research 2010; 3(11): 1435-1442.
  19. Li J, Liu Y, Wang C et al. Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma. Scientific reports 2015; 5: 12921.
  20. Pan C, Yan X, Li H et al. Systematic literature review and clinical validation of circulating microRNAs as diagnostic biomarkers for colorectal cancer. Oncotarget 2017; 8(40): 68317.
  21. Kanaan Z, Roberts H, Eichenberger MR et al. A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer. Annals of surgery 2013; 258(3): 400-408.
  22. Guo X, Yao S, Zhu D, Zhao H, Xu Y. Significance of serum miRNA-17-3p in diagnosis of colon cancer. World Chinese Journal of Digestology 2014; 22(30): 4701-4704.
  23. Zhang S. The diagnostic role of CEA plus miR-17-3p detections in colon cancer, Suzhou University; 2013.
  24. Lijmer JG, Bossuyt PM, Heisterkamp SH. Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Statistics in medicine 2002; 21(11): 1525-1537.
  25. Walter S. Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data. Statistics in medicine 2002; 21(9): 1237-1256.
  26. Jones CM, Athanasiou T. Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. The Annals of thoracic surgery 2005; 79(1): 16-20.
  27. Glas AS, Lijmer JG, Prins MH, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. Journal of clinical epidemiology 2003; 56(11): 1129-1135.
  28. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994: 1088-1101.
  29. Schetter AJ, Leung SY, Sohn JJ et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. Jama 2008; 299(4): 425-436.
  30. Wu WK, Law PT, Lee CW et al. MicroRNA in colorectal cancer: from benchtop to bedside. Carcinogenesis 2010; 32(3): 247-253.
  31. Chen X, Ba Y, Ma L et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell research 2008; 18(10): 997.
  32. Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids”the mix of hormones and biomarkers. Nature reviews Clinical oncology 2011; 8(8): 467.
  33. Mitchell PS, Parkin RK, Kroh EM et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences 2008; 105(30): 10513-10518.
  34. Allen JE, El-Deiry WS. Circulating tumor cells and colorectal cancer. Current colorectal cancer reports 2010; 6(4): 212-220.
  35. Force UPST. Screening for colorectal cancer: recommendation and rationale. Annals of internal medicine 2002; 137(2): 129.
Read More

References


Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends”an update. Cancer Epidemiology and Prevention Biomarkers 2016; 25(1): 16-27.

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. cell 2004; 116(2): 281-297.

Calin GA, Croce CM. MicroRNA signatures in human cancers. Nature reviews cancer 2006; 6(11): 857.

Ng EK, Tsui NB, Lam NY et al. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clinical chemistry 2002; 48(8): 1212-1217.

Silva J, Rodriguez R, Garcia J et al. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 2002; 50(4): 530-534.

Barbarotto E, Schmittgen TD, Calin GA. MicroRNAs and cancer: profile, profile, profile. International journal of cancer 2008; 122(5): 969-977.

Lanza G, Ferracin M, Gafí R et al. mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Molecular cancer 2007; 6(1): 54.

Monzo M, Navarro A, Bandres E et al. Overlapping expression of microRNAs in human embryonic colon and colorectal cancer. Cell research 2008; 18(8): 823.

Ayaz L, Görür A, Yaroğlu HY, í–zcan C, Tamer L. Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. Journal of cancer research and clinical oncology 2013; 139(9): 1499-1506.

Humphreys KJ, McKinnon RA, Michael MZ. miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PloS one 2014; 9(11): e112288.

Fang L, Li H, Wang L et al. MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. Oncotarget May 30 2014; 5(10): 2974-2987.

Faltejskova P, Bocanek O, Sachlova M et al. Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: evidence against their usage as biomarkers in colorectal cancer. Cancer Biomarkers 2013; 12(4-5): 199-204.

Whiting PF, Rutjes AW, Westwood ME et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Annals of internal medicine 2011; 155(8): 529-536.

Fu F, Jiang W, Zhou L, Chen Z. Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer. Translational oncology 2018; 11(2): 221-232.

Zekri A-RN, Youssef ASE-D, Lotfy MM et al. Circulating serum miRNAs as diagnostic markers for colorectal cancer. PLoS One 2016; 11(5): e0154130.

Zhu J, Dong H, Zhang Q, Zhang S. Combined assays for serum carcinoembryonic antigen and microRNA"‘17-3p offer improved diagnostic potential for stage I/II colon cancer. Molecular and clinical oncology 2015; 3(6): 1315-1318.

Zhang J, Raju GS, Chang DW, Lin SH, Chen Z, Wu X. Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer. Cancer 2018; 124(4): 785-796.

Koga Y, Yasunaga M, Takahashi A et al. MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening. Cancer prevention research 2010; 3(11): 1435-1442.

Li J, Liu Y, Wang C et al. Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma. Scientific reports 2015; 5: 12921.

Pan C, Yan X, Li H et al. Systematic literature review and clinical validation of circulating microRNAs as diagnostic biomarkers for colorectal cancer. Oncotarget 2017; 8(40): 68317.

Kanaan Z, Roberts H, Eichenberger MR et al. A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer. Annals of surgery 2013; 258(3): 400-408.

Guo X, Yao S, Zhu D, Zhao H, Xu Y. Significance of serum miRNA-17-3p in diagnosis of colon cancer. World Chinese Journal of Digestology 2014; 22(30): 4701-4704.

Zhang S. The diagnostic role of CEA plus miR-17-3p detections in colon cancer, Suzhou University; 2013.

Lijmer JG, Bossuyt PM, Heisterkamp SH. Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Statistics in medicine 2002; 21(11): 1525-1537.

Walter S. Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data. Statistics in medicine 2002; 21(9): 1237-1256.

Jones CM, Athanasiou T. Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. The Annals of thoracic surgery 2005; 79(1): 16-20.

Glas AS, Lijmer JG, Prins MH, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. Journal of clinical epidemiology 2003; 56(11): 1129-1135.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994: 1088-1101.

Schetter AJ, Leung SY, Sohn JJ et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. Jama 2008; 299(4): 425-436.

Wu WK, Law PT, Lee CW et al. MicroRNA in colorectal cancer: from benchtop to bedside. Carcinogenesis 2010; 32(3): 247-253.

Chen X, Ba Y, Ma L et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell research 2008; 18(10): 997.

Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids”the mix of hormones and biomarkers. Nature reviews Clinical oncology 2011; 8(8): 467.

Mitchell PS, Parkin RK, Kroh EM et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences 2008; 105(30): 10513-10518.

Allen JE, El-Deiry WS. Circulating tumor cells and colorectal cancer. Current colorectal cancer reports 2010; 6(4): 212-220.

Force UPST. Screening for colorectal cancer: recommendation and rationale. Annals of internal medicine 2002; 137(2): 129.

Author biographies is not available.
Download this PDF file
PDF
Statistic
Read Counter : 286 Download : 138
 
 

Author Resources

  •    Author Guidelines
  •    Submission
  •    Articles Processing Charges
  •    Download Manuscript Template

Meet Our Editorial Team

Jean Michel Maixent
Editor-inChief
Laboratoire PROTEE, Université de Toulon, CS 60584 - 83041 Toulon Cedex 9,
France
Danial Kahrizi
Associate to the Editor-in-Chief
Razi University, Iran
S.J.S. Flora
Associate to the Editor-in-Chief
National Institute of Pharmaceutical Education and Research (NIPER),
India
Joël Grillasca
Associate to the Editor-in-Chief
Laboratoire PROTEE, Université de Toulon, CS 60584 - 83041 Toulon Cedex 9,
France

 

Read More

 

Impact Factor: 1.77

SCImago Journal & Country Rank


 


Aims and Scope

Cellular and Molecular Biology (CMB) is an international peer-reviewed journal in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology...

read more

Author Guidelines

Before submitting your manuscript, be sure that it is written in correct and understandable language (if you have difficulties in this matter, you can contact the publisher...

read more

Editorial Policies

Focus and Scope: Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor...

read more

Open Access

Manuscript Submission

Authors, especially from non-English speaking countries, are warmly invited to use a language-editing service or a revision by a native speaker for a correct English...

read more

Article Processing Charge

Article Processing Charges

We value the privacy of any published material that confirm by the author. We encourage the author to read the details about the ethics or any submission guidelines on this link...

read more

Publication Ethics
 

Reviewers Guidelines

Reviewers are advised to consider the following important aspects of a manuscript when conducting the review...

read more

 

 

Published Volume By Year
2022
Volume 68 : Issue 1
2021
Volume 67 : Issue 6
Volume 67 : Issue 5
Volume 67 : Issue 4
Volume 67 : Issue 3
Volume 67 : Issue 2
Volume 67 : Issue 1
2020
Volume 66 : Issue 8
Volume 66 : Issue 7
Volume 66 : Issue 6
Volume 66 : Issue 5
Volume 66 : Issue 4
Volume 66 : Issue 3
Volume 66 : Issue 2
Volume 66 : Issue 1
2019
Volume 65 : Issue 8
Volume 65 : Issue 7
Volume 65 : Issue 6
Volume 65 : Issue 5
Volume 65 : Issue 4
Volume 65 : Issue 3
Volume 65 : Issue 2
Volume 65 : Issue 1
2018
Volume 64 : Issue 15
Volume 64 : Issue 14
Volume 64 : Issue 13
Volume 64 : Issue 12
Volume 64 : Issue 11
Volume 64 : Issue 10
Volume 64 : Issue 9
Volume 64 : Issue 8
Volume 64 : Issue 7
Volume 64 : Issue 6
Volume 64 : Issue 5
Volume 64 : Issue 4
Volume 64 : Issue 3
Volume 64 : Issue 2
Volume 64 : Issue 1
2017
Volume 63 : Issue 12
Volume 63 : Issue 11
Volume 63 : Issue 10
Volume 63 : Issue 9
Volume 63 : Issue 8
Volume 63 : Issue 7
Volume 63 : Issue 6
Volume 63 : Issue 5
Volume 63 : Issue 4
Volume 63 : Issue 3
Volume 63 : Issue 2
Volume 63 : Issue 1
2016
Volume 62 : Issue 14
Volume 62 : Issue 13
Volume 62 : Issue 12
Volume 62 : Issue 11
Volume 62 : Issue 10
Volume 62 : Issue 9
Volume 62 : Issue 8
Volume 62 : Issue 7
Volume 62 : Issue 6
Volume 62 : Issue 5
Volume 62 : Issue 4
Volume 62 : Issue 3
Volume 62 : Issue 2
Volume 62 : Issue 1
2015
Volume 61 : Issue 8
Volume 61 : Issue 7
Volume 61 : Issue 6
Volume 61 : Issue 5
Volume 61 : Issue 4
Volume 61 : Issue 3
Volume 61 : Issue 2
Volume 61 : Issue 1
2014
Volume 60 : Issue 6
Volume 60 : Issue 5
Volume 60 : Issue 4
Volume 60 : Issue 3
Volume 60 : Issue 2
Volume 60 : Issue 1
2013
Volume 59 : Issue 2
Volume 59 : Issue 1
2012
Volume 58 : Issue 2
Volume 58 : Issue 1
2011
Volume 57 : Issue 2
Volume 57 : Issue 1
2010
Volume 56 : Issue 3
Volume 56 : Issue 2
Volume 56 : Issue 1
2009
Volume 55 : Issue 4
Volume 55 : Issue 3
Volume 55 : Issue 2
Volume 55 : Issue 1
2008
Volume 54 : Issue 2
Volume 54 : Issue 1
2007
Volume 53 : Issue 6
Volume 53 : Issue 3
Volume 53 : Issue 2
Volume 53 : Issue 1
Themes by Openjournaltheme.com

Most read articles by the same author(s)

  • Hongdan Ma, Lei Wang, Wen Lv, Zheng Lv, Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway , Cellular and Molecular Biology: Vol. 66 No. 7: Issue 7
  • Huiping Zhu, Jianjun Dong, Xufeng Xie, Lei Wang, Comparison between the molecular diagnostic test and chest X-ray combined with multi-slice spiral CT in the diagnosis of lobar pneumonia , Cellular and Molecular Biology: Vol. 67 No. 3 (2021): Issue 3
  • Jing Zhang, Liang Dong, Shuzhen Zhang, Lei Wang, Analysis of the clinical efficacy of leuprolide acetate in the treatment of obese patients with endometriosis and its role on the expression of MIF gene , Cellular and Molecular Biology: Vol. 67 No. 4 (2021): Issue 4
  • Guoqiang Yan, Tao Liu, Libin Yin, Zhenhua Kang, Lei Wang, Levels of peripheral Th17 cells and serum Th17-related cytokines in patients with colorectal cancer: a meta-analysis , Cellular and Molecular Biology: Vol. 64 No. 6: Advances in mechanism and treatment strategy of cancer

 Address

23 Avenue de l'observatoire Paris France

  Contact Info

editorial.office@cellmolbiol.org
© 2021 Site Owner, All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Licensed under Creative Commons License a Creative Commons Attribution 4.0 International License.
Themes by Openjournaltheme.com