Poria cocos Wolf extracts represses pigmentation in vitro and in vivo

HyunKyung Lee; Hwa Jun Cha

doi:10.14715/cmb/2018.64.5.13

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Vol. 64 No. 5: Issue 5

Issue Published : May 1, 2018

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Poria cocos Wolf extracts represses pigmentation in vitro and in vivo

https://doi.org/10.14715/cmb/2018.64.5.13

HyunKyung Lee

GeneCellPharm Corporation, 2nd Enterprise Research Building, 194-41 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 361-951, Republic of Korea

Hwa Jun Cha

Department of Beauty Care & Cosmetics, Osan University, Osan, Gyeonggi 18119, Republic of Korea

Corresponding Author(s) : Hwa Jun Cha

michael83@naver.com

Cellular and Molecular Biology, Vol. 64 No. 5: Issue 5
Article Published : April 30, 2018

Abstract

In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and UV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. In our present study, we show that Poria cocos Wolf extracts decreased melanin synthesis in B16F10. And then this inhibition of melanogenesis was provoked by regulation of tyrosinase activity and tyrosinase and MITF expression. Moreover, Poria cocos Wolf extracts contained cream improved skin tone using increase of bright value. Overall, these results provide evidence to potential agent for whitening to be used in cosmetic products.

Keywords

Melanogenesis Tyrosinase MITF Poria cocos Wolf B16F10 Whitening.

Lee, H., & Cha, H. J. (2018). Poria cocos Wolf extracts represses pigmentation in vitro and in vivo. Cellular and Molecular Biology, 64(5), 80–84. https://doi.org/10.14715/cmb/2018.64.5.13

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References

Boer M, Duchnik E, Maleszka R, Marchlewicz M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Postepy. Dermatol. Alergol. 2016; 33: 1-5.
Briggaman RA. Epidermal-dermal interactions in adult skin. J. Invest. Dermatol. 1982; 79 Suppl 1: 21s-24s.
Cichorek M, Wachulska M, Stasiewicz A, TymiÅ„ska A. Skin melanocytes: biology and development. Postepy. Dermatol. Alergol. 2013; 30: 34-41.
Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem. Photobiol. 2008;84: 539-549.
Ebanks JP, Wickett RR, Boissy RE. Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int. J. Mol. Sci. 2009; 10: 4066-4087.
Handel AC, Miot LD, Miot HA. Melasma: a clinical and epidemiological review. An. Bras. Dermatol. 2014; 89 :771-782.
Park HY, Kosmadaki M, Yaar M, Gilchrest BA. Cellular mechanisms regulating human melanogenesis. Cell. Mol. Life Sci. 2009; 66: 1493-1506.
Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol. Rev. 2004; 84: 1155-1228.
Videira IF, Moura DF, Magina S. Mechanisms regulating melanogenesis. An. Bras. Dermatol. 2013; 88: 76-83.
Eller MS, Ostrom K, Gilchrest BA. DNA damage enhances melanogenesis. Proc. Natl. Acad. Sci. U. S. A. 1996; 93: 1087-1092.
Gilchrest BA, Park HY, Eller MS, Yaar M. Mechanisms of ultraviolet light-induced pigmentation. Photochem. Photobiol. 1996; 63: 1-10.
Thody AJ, Graham A. Does alpha-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res. 1998; 11: 265-274.
Gillbro JM, Olsson MJ. 2011. The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches. Int. J. Cosmet. Sci. 33: 210-221.
Sugumaran M. Molecular mechanisms for mammalian melanogenesis. Comparison with insect cuticular sclerotization. FEBS Lett. 1991; 295: 233-239.
Boda RH, Wani AH, Zargar MA, Ganie BA, Wani BA, Ganie SA. Nutritional values and antioxidant potential of some edible mushrooms of Kashmir valley. Pak J Pharm Sci 2012; 25: 623-7.
Money NP. Are mushrooms medicinal? Fungal. Biol. 2016; 120: 449-53.
Xu T, Beelman RB, Lambert JD. The cancer preventive effects of edible mushrooms. Anticancer Agents Med. Chem. 2012; 12: 1255-1263.
Fuchs SM, Heinemann C, Schliemann-Willers S, Härtl H, Fluhr JW, Elsner P. Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis. Skin Res. Technol. 2006; 12: 223-227.
Ríos JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011; 77: 681-691.
Sun Y. Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. Int. J. Biol. Macromol. 2014; 68: 131-134.
Wu ZL, Ren H, Lai WY, Lin S, Jiang RY, Ye TC, Shen QB, Zeng QC, Xu DL. Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure. J. Ethnopharmacol. 2014; 155: 563-571.
Cheng S, Swanson K, Eliaz I, McClintick JN, Sandusky GE, Sliva D. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. PLoS One. 2015; 10: e0122270.
Zhang M, Chiu LC, Cheung PC, Ooi VE. Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction. Oncol. Rep. 2006; 15: 637-643.
Ferguson CA, Kidson SH. The regulation of tyrosinase gene transcription. Pigment Cell Res. 1997; 10: 127-138.
Mosse CA, Hsu W, Engelhard VH. Tyrosinase degradation via two pathways during reverse translocation to the cytosol. Biochem. Biophys. Res. Commun. 2001; 285: 313-319.
Gaggioli C, Buscí R, Abbe P, Ortonne JP, Ballotti R. Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes. Pigment Cell Res. 2003; 16: 374-382.
Wan P, Hu Y, He L. Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors. Mol. Cell. Biochem. 2011; 354: 241-246.
Imokawa G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res. 2004; 17: 96-110.
Joo DH, Cha HJ, Kim K, Jung M, Ko JM, An IS, Lee SN, Jang HH, Bae S, Roh NK, Ahn KJ, An S. Benzo(a)pyrene represses melanogenesis in B16F10 mouse melanoma cells. Mol. Cell. Toxicol. 2015; 11: 349-355.
Hedley SJ, Gawkrodger DJ, Weetman AP, Macneil S. alpha-MSH and melanogenesis in normal human adult melanocytes. Pigment Cell Res. 1998; 11: 45-56.
Lee S, Oh DG, Lee S, Kim GR, Lee JS, Son YK, Bae CH, Yeo J, Lee CH. Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities. Molecules. 2015; 20: 19719-19734.

References

Boer M, Duchnik E, Maleszka R, Marchlewicz M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Postepy. Dermatol. Alergol. 2016; 33: 1-5.

Briggaman RA. Epidermal-dermal interactions in adult skin. J. Invest. Dermatol. 1982; 79 Suppl 1: 21s-24s.

Cichorek M, Wachulska M, Stasiewicz A, TymiÅ„ska A. Skin melanocytes: biology and development. Postepy. Dermatol. Alergol. 2013; 30: 34-41.

Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem. Photobiol. 2008;84: 539-549.

Ebanks JP, Wickett RR, Boissy RE. Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int. J. Mol. Sci. 2009; 10: 4066-4087.

Handel AC, Miot LD, Miot HA. Melasma: a clinical and epidemiological review. An. Bras. Dermatol. 2014; 89 :771-782.

Park HY, Kosmadaki M, Yaar M, Gilchrest BA. Cellular mechanisms regulating human melanogenesis. Cell. Mol. Life Sci. 2009; 66: 1493-1506.

Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol. Rev. 2004; 84: 1155-1228.

Videira IF, Moura DF, Magina S. Mechanisms regulating melanogenesis. An. Bras. Dermatol. 2013; 88: 76-83.

Eller MS, Ostrom K, Gilchrest BA. DNA damage enhances melanogenesis. Proc. Natl. Acad. Sci. U. S. A. 1996; 93: 1087-1092.

Gilchrest BA, Park HY, Eller MS, Yaar M. Mechanisms of ultraviolet light-induced pigmentation. Photochem. Photobiol. 1996; 63: 1-10.

Thody AJ, Graham A. Does alpha-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res. 1998; 11: 265-274.

Gillbro JM, Olsson MJ. 2011. The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches. Int. J. Cosmet. Sci. 33: 210-221.

Sugumaran M. Molecular mechanisms for mammalian melanogenesis. Comparison with insect cuticular sclerotization. FEBS Lett. 1991; 295: 233-239.

Boda RH, Wani AH, Zargar MA, Ganie BA, Wani BA, Ganie SA. Nutritional values and antioxidant potential of some edible mushrooms of Kashmir valley. Pak J Pharm Sci 2012; 25: 623-7.

Money NP. Are mushrooms medicinal? Fungal. Biol. 2016; 120: 449-53.

Xu T, Beelman RB, Lambert JD. The cancer preventive effects of edible mushrooms. Anticancer Agents Med. Chem. 2012; 12: 1255-1263.

Fuchs SM, Heinemann C, Schliemann-Willers S, Härtl H, Fluhr JW, Elsner P. Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis. Skin Res. Technol. 2006; 12: 223-227.

Ríos JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011; 77: 681-691.

Sun Y. Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. Int. J. Biol. Macromol. 2014; 68: 131-134.

Wu ZL, Ren H, Lai WY, Lin S, Jiang RY, Ye TC, Shen QB, Zeng QC, Xu DL. Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure. J. Ethnopharmacol. 2014; 155: 563-571.

Cheng S, Swanson K, Eliaz I, McClintick JN, Sandusky GE, Sliva D. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. PLoS One. 2015; 10: e0122270.

Zhang M, Chiu LC, Cheung PC, Ooi VE. Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction. Oncol. Rep. 2006; 15: 637-643.

Ferguson CA, Kidson SH. The regulation of tyrosinase gene transcription. Pigment Cell Res. 1997; 10: 127-138.

Mosse CA, Hsu W, Engelhard VH. Tyrosinase degradation via two pathways during reverse translocation to the cytosol. Biochem. Biophys. Res. Commun. 2001; 285: 313-319.

Gaggioli C, Buscí R, Abbe P, Ortonne JP, Ballotti R. Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes. Pigment Cell Res. 2003; 16: 374-382.

Wan P, Hu Y, He L. Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors. Mol. Cell. Biochem. 2011; 354: 241-246.

Imokawa G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res. 2004; 17: 96-110.

Joo DH, Cha HJ, Kim K, Jung M, Ko JM, An IS, Lee SN, Jang HH, Bae S, Roh NK, Ahn KJ, An S. Benzo(a)pyrene represses melanogenesis in B16F10 mouse melanoma cells. Mol. Cell. Toxicol. 2015; 11: 349-355.

Hedley SJ, Gawkrodger DJ, Weetman AP, Macneil S. alpha-MSH and melanogenesis in normal human adult melanocytes. Pigment Cell Res. 1998; 11: 45-56.

Lee S, Oh DG, Lee S, Kim GR, Lee JS, Son YK, Bae CH, Yeo J, Lee CH. Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities. Molecules. 2015; 20: 19719-19734.