Issue

Vol. 63 No. 9: Issue 9

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Predictive role of cytokines IL-10, IL-12 and TNF-α gene polymorphisms for the development of osteonecrosis of the femoral head in the Chinese Han population

https://doi.org/10.14715/cmb/2017.63.9.23
L. Yuan
Department of Joint Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China
W. Li
Department of Joint Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China
Z. B. Tian
Department of Joint Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China
Y. Li
Department of Joint Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China
S. Sun
Department of Joint Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China

Corresponding Author(s) : S. Sun

sunshuijn@sina.com

Cellular and Molecular Biology, Vol. 63 No. 9: Issue 9

Abstract

The progressive neurodegenerative process in osteonecrosis of the femoral head (ONFH) is accompanied by chronic inflammation, including activation of microglia and astrocytes that express pro-inflammatory cytokines. Up to now, numerous studies of genetic epidemiology have assessed the association of anti- and pro-inflammation cytokines gene polymorphisms and risk of ONFH in different populations, but contradictory results were obtained due to the genetic heterogeneity of in different populations. In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10) rs1800872, IL-12 rs3212227 and tumor necrosis factor-(TNF-α) rs1800629 polymorphism in ONFH. Single nucleotide polymorphism (SNP) locus was genotyped using the PCR-RFLP method. The genotypic and allele frequencies of TNF-α and IL-10 did not show significant difference between ONFH patients and normal controls. However, the frequencies of wild (AA) and homozygous mutant (CC) genotype of IL-12 rs3212227 in controls were more than that in ONFH patients, but that of the heterozygous genotype was more in patients with ONFH. Thus, our findings indicate that IL-12 rs3212227 AC genotype confer genetically susceptibility to ONFH in the Chinese Han population.

Keywords

Osteonecrosis of the femoral head IL-10 IL-12 TNF-α Polymorphism.
Yuan, L., Li, W., Tian, Z. B., Li, Y., & Sun, S. (2017). Predictive role of cytokines IL-10, IL-12 and TNF-α gene polymorphisms for the development of osteonecrosis of the femoral head in the Chinese Han population. Cellular and Molecular Biology, 63(9), 144–149. https://doi.org/10.14715/cmb/2017.63.9.23
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Glueck CJ, Freiberg RA, Oghene J, Fontaine RN, Wang P. Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur. J Bone Joint Surg Am 2007; 89:2460-8.
  2. Wang Z, Zhang Y, Kong X, Li S, Hu Y, Wang R, Li Y, Lu C, Lin N, Chen W. Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population. Diagn Pathol 2013; 8:186.
  3. Song Y, Du Z, Yang Q, Ren M, Sui Y, Wang Q, Wang A, Zhao H, Wang J, Zhang G. Associations of IGFBP3 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China. DNA Cell Biol 2016; 35:836-44.
  4. Hirata T, Fujioka M, Takahashi KA, Arai Y, Asano T, Ishida M, Kuribayashi M, Akioka K, Okamoto M, Yoshimura N, et al. ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantation. J Orthop Sci 2007; 12:199-206.
  5. La Ferla F, Paolicchi E, Crea F, Cei S, Graziani F, Gabriele M, Danesi R. An aromatase polymorphism (g.132810C>T) predicts risk of bisphosphonate-related osteonecrosis of the jaw. Biomark Med 2012; 6:201-9.
  6. Zhong DN, Wu JZ, Li GJ. Association between CYP2C8 (rs1934951) polymorphism and bisphosphonate-related osteonecrosis of the jaws in patients on bisphosphonate therapy: a meta-analysis. Acta Haematol 2013; 129:90-5.
  7. Sarasquete ME, Garcia-Sanz R, Marin L, Alcoceba M, Chillon MC, Balanzategui A, Santamaria C, Rosinol L, de la Rubia J, Hernandez MT, et al. Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis. Blood 2008; 112:2709-12.
  8. Lee MS, Chang YH, Chao EK, Shih CH. Conditions before collapse of the contralateral hip in osteonecrosis of the femoral head. Chang Gung Med J 2002; 25:228-37.
  9. Aigner N, Schneider W, Eberl V, Knahr K. Core decompression in early stages of femoral head osteonecrosis--an MRI-controlled study. Int Orthop 2002; 26:31-5.
  10. Beksac K, Sonmez C, Cetin B, Kismali G, Sel T, Tuncer Y, Kosova F. Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma. The International journal of biological markers 2016; 31:e446-e50.
  11. Lumachi F, Basso SM, Orlando R. Cytokines, thyroid diseases and thyroid cancer. Cytokine 2010; 50:229-33.
  12. Kubaszek A, Pihlajamaki J, Komarovski V, Lindi V, Lindstrom J, Eriksson J, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, et al. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 2003; 52:1872-6.
  13. Mozzati M, Martinasso G, Maggiora M, Scoletta M, Zambelli M, Carossa S, Oraldi M, Muzio G, Canuto RA. Oral mucosa produces cytokines and factors influencing osteoclast activity and endothelial cell proliferation, in patients with osteonecrosis of jaw after treatment with zoledronic acid. Clin Oral Investig 2013; 17:1259-66.
  14. Hungerford MW, Mont MA. [Potential uses of cytokines and growth factors in treatment of osteonecrosis]. Orthopade 2000; 29:442-8.
  15. Oleksyk TK, Shrestha S, Truelove AL, Goedert JJ, Donfield SM, Phair J, Mehta S, O'Brien SJ, Smith MW. Extended IL10 haplotypes and their association with HIV progression to AIDS. Genes and Immunity 2009; 10:309-22.
  16. Dmello DM, Ariyanto I, Estiasari R, Halstrom S, Gaff J, Lee S, Price P. Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy. Hum Immunol 2017; 78:387-90.
  17. Zheng Y, Wang M, Tian T, Liu K, Liu X, Zhai Y, Lin S, Yang P, Li S, Dai Z, et al. Role of interleukin-12 gene polymorphisms in the onset risk of cancer: a meta-analysis. Oncotarget 2017; 8:29795-807.
  18. Zhang P, Wu X, Li G, He Q, Dai H, Ai C, Shi J. Tumor necrosis factor-alpha gene polymorphisms and susceptibility to ischemic heart disease: A systematic review and meta-analysis. Medicine (Baltimore) 2017; 96:e6569.
  19. Conzemius MG, Brown TD, Zhang Y, Robinson RA. A new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure. J Orthop Res 2002; 20:303-9.
  20. Di Martino MT, Arbitrio M, Guzzi PH, Leone E, Baudi F, Piro E, Prantera T, Cucinotto I, Calimeri T, Rossi M, et al. A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling. Br J Haematol 2011; 154:529-33.
  21. Zeng Z, Wang B, Pan H. Relation between osteonecrosis of the femoral head and PAI-1 4G/5G gene polymorphism: a meta-analysis. Int J Clin Exp Med 2015; 8:20337-42.
  22. Miller KD, Masur H, Jones EC, Joe GO, Rick ME, Kelly GG, Mican JM, Liu S, Gerber LH, Blackwelder WC, et al. High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med 2002; 137:17-25.
  23. Aguiar De Aragao P, Lemos RB, Aquino MZ, Souza Marques HH. Hyperlipidaemia a risk factor for femoral head osteonecrosis (Legg-Calv -Perthes-like disease) in children with AIDS: case report. Braz J Infect Dis 2002; 6:142-5.
  24. Yang JW, Koo KH, Lee MC, Yang P, Noh MD, Kim SY, Kim KI, Ha YC, Joun MS. Mechanics of femoral head osteonecrosis using three-dimensional finite element method. Arch Orthop Trauma Surg 2002; 122:88-92.
  25. Shang X, Luo Z, Li X, Hu F, Zhao Q, Zhang W. Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. Biomed Rep 2013; 1:594-8.
  26. Bond J, Adams S, Richards S, Vora A, Mitchell C, Goulden N. Polymorphism in the PAI-1 (SERPINE1) gene and the risk of osteonecrosis in children with acute lymphoblastic leukemia. Blood 2011; 118:2632-3.
  27. Yin JM, Liu Z, Zhao SC, Guo YJ, Liu ZT. Relationship between the Apolipoprotein AI, B gene polymorphism and the risk of non-traumatic osteonecrosis. Lipids Health Dis 2014; 13:149.
  28. Glueck CJ, Freiberg RA, Boppana S, Wang P. Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis. J Bone Joint Surg Am 2008; 90:2220-9.
  29. Gross CE, Sershon RA, Frank JM, Easley ME, Holmes GB, Jr. Treatment of Osteonecrosis of the Talus. JBJS Rev 2016; 4.
  30. Liu B, Cao Y, Wang D, Yao G, Bi Z. Vascular endothelial growth factor -634G/C polymorphism associated with osteonecrosis of the femoral head in a Chinese population. Genet Test Mol Biomarkers 2012; 16:739-43.
  31. Zhao Y, Du Y, Zhao S, Guo Z. Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer. OncoTargets and therapy 2015; 8:421-5.
  32. Gao YW, Xu M, Xu Y, Li D, Zhou S. Effect of three common IL-17 single nucleotide polymorphisms on the risk of developing gastric cancer. Oncology letters 2015; 9:1398-402.
  33. Kakkoura MG, Demetriou CA, Loizidou MA, Loucaides G, Neophytou I, Marcou Y, Hadjisavvas A, Kyriacou K. Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case-control study in the Greek-Cypriot female population. Genes & nutrition 2015; 10:453.
  34. Ge J, Zhu L, Zhou J, Li G, Li Y, Li S, Wu Z, Rong J, Yuan H, Liu Y, et al. Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese. Journal of cancer research and clinical oncology 2015; 141:1533-44.
  35. Geredeli C, Artac M, Yildirim S, Inal A, Dede I, Guler T, Boruban MC, Koral L, Karaagac M, Zamani AG, et al. Prognostic value of ERCC1, ERCC2, XRCC1, and TP53 single nucleotide polymorphisms in patients with early-stage non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015; 36:4279-85.
  36. Zhu S, Shao B, Hao Y, Li Z, Liu H, Li H, Wang M, Wang K. No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: a meta-analysis. Cancer biomarkers : section A of Disease markers 2015; 15:89-97.
  37. Wu GC, Zhang ZT. Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population. Medical oncology 2015; 32:401.
  38. Papewalis C, Jacobs B, Wuttke M, Ullrich E, Baehring T, Fenk R, Willenberg HS, Schinner S, Cohnen M, Seissler J, et al. IFN-alpha skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo. Journal of immunology 2008; 180:1462-70.
  39. Solini A, Cuccato S, Ferrari D, Santini E, Gulinelli S, Callegari MG, Dardano A, Faviana P, Madec S, Di Virgilio F, et al. Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease? Endocrinology 2008; 149:389-96.
  40. Stanciu AE, Serdarevic N, Hurduc AE, Stanciu MM. IL-4, IL-10 and high sensitivity-CRP as potential serum biomarkers of persistent/recurrent disease in papillary thyroid carcinoma with/without Hashimoto's thyroiditis. Scandinavian journal of clinical and laboratory investigation 2015; 75:539-48.
  41. Zhang YM, Zhou XC, Xu Z, Tang CJ. Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk. Genet Mol Res 2012; 11:3389-97.
  42. Farahat O, Salah M, Mokhtar A, Abouelfetoh F, Labib D, Baz H. The association of promoter gene polymorphisms of the tumor necrosis factor-alpha and interleukin-10 with severity of lactic acidosis during liver transplantation surgery. Transplant Proc 2012; 44:1307-13.
  43. Firouze Moqadam I, Najafi S, Mohammadzadeh M, Zare Bidoki A, Yousefi H, Farhadi E, Tonekaboni A, Meighani G, Mohammadzadeh M, Amirzargar AA, et al. Lack of Association between Interleukin-12 Gene Polymorphisms and Recurrent Aphthous Stomatitis. Avicenna J Med Biotechnol 2016; 8:200-1.
  44. Dundar NO, Gencpinar P, Sallakci N, Duman O, Haspolat S, Anlar B, Yegin O. Interleukin-12 (-1188) A/C and interferon-gamma (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients. J Neurovirol 2016; 22:661-5.
  45. Chang SW, Xu GQ, Fan YL. Association of interleukin-12 gene polymorphisms with cancer susceptibility: a meta-analysis. Int J Clin Exp Med 2015; 8:5317-22.
  46. Aytekin N, Akcali C, Pehlivan S, Kirtak N, Inaloz S. Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata. J Int Med Res 2015; 43:526-34.
  47. Ebadi N, Jahed M, Mivehchi M, Majidizadeh T, Asgary M, Hosseini SA. Interleukin-12 and interleukin-6 gene polymorphisms and risk of bladder cancer in the Iranian population. Asian Pac J Cancer Prev 2014; 15:7869-73.
  48. Grzegorzewska AE, Wobszal PM, Mostowska A, Jagodzinski PP. Antibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients. BMC Nephrol 2012; 13:75.
  49. Orozco G, Gonzalez-Gay MA, Paco L, Lopez-Nevot MA, Guzman M, Pascual-Salcedo D, Balsa A, Martin J. Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis. Human immunology 2005; 66:710-5.
  50. Navaglia F, Basso D, Zambon CF, Ponzano E, Caenazzo L, Gallo N, Falda A, Belluco C, Fogar P, Greco E, et al. Interleukin 12 gene polymorphisms enhance gastric cancer risk in H pylori infected individuals. J Med Genet 2005; 42:503-10.
  51. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, le Souef PN, Lathrop GM, et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383:247-50.
  52. Schluter B, Erren M, Schotte H, Junker R, Rust S, Assmann G. The mutagenically separated polymerase chain reaction is a rapid and reliable method for genotyping of the tumour necrosis factor-alpha promoter polymorphism (-308 G/A). Clinica chimica acta; international journal of clinical chemistry 2002; 320:135-8.
  53. Horneff G, Klein A, Oommen PT, Hospach A, Foeldvari I, Feddersen I, Minden K. OP0219 update on malignancies in children with juvenile idiopathic arthritis in the German BIKER Registry. Clinical and experimental rheumatology 2016; 34:1113-20.
  54. Yang SW, Kang SH, Kim KR, Choi IH, Chang HS, Oh YL, Hong SW. Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect? Journal of pathology and translational medicine 2016; 50:377-84.
  55. Jedlickova H, Durcanska V, Vasku V. Paraneoplastic Scleroderma: Are There Any Clues? Acta dermatovenerologica Croatica : ADC 2016; 24:78-80.
  56. Kobawala TP, Trivedi TI, Gajjar KK, Patel DH, Patel GH, Ghosh NR. Significance of TNF-alpha and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma. Journal of thyroid research 2016; 2016:8143695.
  57. Kim SH, Kang JG, Kim CS, Ihm SH, Choi MG, Yoo HJ, Lee SJ. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. Anticancer research 2015; 35:6529-37.
  58. Lv N, Shan Z, Gao Y, Guan H, Fan C, Wang H, Teng W. Twist1 regulates the epithelial-mesenchymal transition via the NF-kappaB pathway in papillary thyroid carcinoma. Endocrine 2016; 51:469-77.
  59. Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ. Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review. Laboratory medicine 2015; 46:140-5.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 1128 Download : 351

Similar Articles

You may also start an advanced similarity search for this article.