Issue
−174 G/C polymorphism of interleukin 6 gene is not significantly different in Turkish professional short and long distance runners
Corresponding Author(s) : Korkut Ulucan
Cellular and Molecular Biology,
Vol. 64 No. 11: Issue 11
Abstract
Interleukin-6 (IL-6) is a kind of multifunctional cytokine and involved in mediating muscle repair metabolism, and therefore athletic capacity. Muscular and circulating IL-6 levels increase in response to physical exercise. Responsible gene coding for IL-6 has a functional polymorphism in its promoter region, -174 G/C (rs1800795). We aimed to analyze the association of G allele and GG genotype in Turkish professional athletes and compare the allelic and genotypic difference between short distance and long distance runners. For this purpose, we enrolled 40 (24 short distance runners and 16 long distance runners) Turkish professional athletes to the study. Real time genotyping procedure was carried out to determine the -174 G/C polymorphism. G allele and GG genotype was more prevalent than the others in our cohort. We found no statistically significant difference between short and long distance runners in the terms of genotype (p=0.07). Our study suggests that-174 G/C polymorphism of IL-6 gene differs in athletes, G allele and GG genotype is higher than the other ones, at least in Turkish athletes, and therefore should be taken into consideration when determining genetic aspects of athletes. Further studies are necessary to confirm our results and show the effect of the given polymorphism in sports science.
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- Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal. muscle hypertrophy. Cell Metab 2008;7:33–44.
- Plewa MC. Altered host response and special in fections in the el- derly. Emerg Ned North Am 1990; 8: 193 – 206.
- PedersenBK,FebbraioMA.Muscleasanendocrineorgan:focuson muscle-derivedinterleukin-6. Physiol Rev 2008;88:1379–406.
- Bennermo M, HeldC,StemmeS,EricssonCG,SilveiraA,GreenF, et al.Geneticpredispositionoftheinterleukin-6responsetoinflam- mation: implicationsforavarietyofmajordiseases? Clin Chem 2004;50:2136–40.
- OrtleppJR,MetrikatJ,VesperK,MevissenV,SchmitzF,Albrecht M, etal.Theinterleukin-6promoterpolymorphismisassociatedwith elevatedleukocyte,lymphocyte,andmonocytecountsandreduced physical fitnessinyounghealthysmokers. J MolMed 2003;81:578–84.
- Yamin C,DuarteJA,OliveiraJM,AmirO,SagivM,EynonN,etal. IL6 (−174) andTNFA(−308) promoterpolymorphismsareassociated with systemiccreatinekinaseresponsetoeccentricexercise. Eur JAppl Physiol 2008;104:579–86.
- Plewa MC. Altered host response and special in fections in the el- derly. Emerg Ned North Am 1990; 8: 193 – 206.
- Petersen AM, PedersenBK. The anti-inflammatory effect of exercise. J ApplPhysiol 2005;98:1154-62.
- Eider J, Cieszczyk P, Leońska-Duniec A et al (2013) Association of the 174 G/C polymorphism of the IL6 gene in Polish power-orientated athletes. J Sports Med Phys Fitness 53(1):88-92.
- Eynon N, Ruiz JR, Meckel Y et al (2011) Is the -174 C/G polymorphism of the IL6 gene associated with elite power performance? A replication study with two different Caucasian cohorts. Exp Physiol 96(2):156-62.
- de Milander L, Stein DJ, Collins M (2009) The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon. Appl Physiol Nutr Metab 34(5):858-65.
- Cenikli A, Nursal AF, Tural E, Polat Y, Tasmektepligil MY, Yigit S. The Correlation between Rs1800795 Variant of IL-6 and Sports Performance among Turkish Elite Athletes. International Journal of Humanities Social Sciences and Education 2016; 3(11); 1-5.
References
Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal. muscle hypertrophy. Cell Metab 2008;7:33–44.
Plewa MC. Altered host response and special in fections in the el- derly. Emerg Ned North Am 1990; 8: 193 – 206.
PedersenBK,FebbraioMA.Muscleasanendocrineorgan:focuson muscle-derivedinterleukin-6. Physiol Rev 2008;88:1379–406.
Bennermo M, HeldC,StemmeS,EricssonCG,SilveiraA,GreenF, et al.Geneticpredispositionoftheinterleukin-6responsetoinflam- mation: implicationsforavarietyofmajordiseases? Clin Chem 2004;50:2136–40.
OrtleppJR,MetrikatJ,VesperK,MevissenV,SchmitzF,Albrecht M, etal.Theinterleukin-6promoterpolymorphismisassociatedwith elevatedleukocyte,lymphocyte,andmonocytecountsandreduced physical fitnessinyounghealthysmokers. J MolMed 2003;81:578–84.
Yamin C,DuarteJA,OliveiraJM,AmirO,SagivM,EynonN,etal. IL6 (−174) andTNFA(−308) promoterpolymorphismsareassociated with systemiccreatinekinaseresponsetoeccentricexercise. Eur JAppl Physiol 2008;104:579–86.
Plewa MC. Altered host response and special in fections in the el- derly. Emerg Ned North Am 1990; 8: 193 – 206.
Petersen AM, PedersenBK. The anti-inflammatory effect of exercise. J ApplPhysiol 2005;98:1154-62.
Eider J, Cieszczyk P, Leońska-Duniec A et al (2013) Association of the 174 G/C polymorphism of the IL6 gene in Polish power-orientated athletes. J Sports Med Phys Fitness 53(1):88-92.
Eynon N, Ruiz JR, Meckel Y et al (2011) Is the -174 C/G polymorphism of the IL6 gene associated with elite power performance? A replication study with two different Caucasian cohorts. Exp Physiol 96(2):156-62.
de Milander L, Stein DJ, Collins M (2009) The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon. Appl Physiol Nutr Metab 34(5):858-65.
Cenikli A, Nursal AF, Tural E, Polat Y, Tasmektepligil MY, Yigit S. The Correlation between Rs1800795 Variant of IL-6 and Sports Performance among Turkish Elite Athletes. International Journal of Humanities Social Sciences and Education 2016; 3(11); 1-5.
