The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Expression of cell adhesion molecule L1 in the long head of biceps tendon
Corresponding Author(s) : K. Alpantaki
apopaki@yahoo.gr
Cellular and Molecular Biology,
Vol. 56 No. 3: General Papers
Abstract
Several studies have proposed that the nervous system participates in nociception and tendon healing process. The neural cell adhesion molecule L1 (L1-CAM), which has an important role in neural development and nociceptive pathways, has been described in the past in the skeletal muscles and tendino-muscular junction. The role of this protein in tendon pathology is unknown. Here, we show that L1-CAM is expressed in human tendons. Samples of the long head of the biceps tendon (LHB) from six patients undergoing shoulder surgery were studied. Both Western blot and immunofluorescence revealed a strong expression pattern of L1-CAM. These L1-CAM positive cells were also Tuj1 positive, suggesting a neuronal origin. To our knowledge this is the first unequivocal evidence of the presence of L1 CAM in human tendons suggesting that it may play a role in organization of extracellular matrix and tendon pain.
Keywords
Tendon of long head of biceps
L1-CAM
shoulder pain
tendinosis.
Alpantaki, K., Savvaki, M., & Karagogeos, D. (2010). Expression of cell adhesion molecule L1 in the long head of biceps tendon. Cellular and Molecular Biology, 56(3), 1286–89. Retrieved from http://cellmolbiol.org/index.php/CMB/article/view/975
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX