Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts

M Sharifi-Rad; G S Tayeboon; J Sharifi-Rad; M Iriti; E M Varoni; S Razazi

Issue

Vol. 62 No. 6: Issue 6

Issue Published : May 30, 2016

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Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts

M Sharifi-Rad

Zabol University of Medical Sciences Zabol Iran

G S Tayeboon

Payamenoor University Department of Biology Tehran Iran

J Sharifi-Rad

Zabol University of Medical Sciences Zabol Medicinal Plants Research Center Zabol Iran

M Iriti

Milan State University Department of Agricultural and Environmental Sciences Milan Italy

E M Varoni

Milan State University Department of Biomedical, Surgical and Dental Sciences Milan Italy

S Razazi

Sharif University of Technology Department of Chemistry Tehran Iran

Corresponding Author(s) : M Sharifi-Rad

Cellular and Molecular Biology, Vol. 62 No. 6: Issue 6
Article Published : May 30, 2016

Abstract

Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (Î±-glucosidase and Î±-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited Î±-amylase, Î±-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P<0.05) inhibited Î±-glucosidase (IC50 532.97 µg/mL), whereas conjugated phenolic extract significantly (P<0.05) inhibited Î±-amylase (IC50 489.73 µg/mL) and ACE (290.06 µg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of Î±-amylase, Î±-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects.

Keywords

Plantaginaceae Î±-amylase Î±-glucosidase angiotension I converting enzyme traditional medicine ethnopharmacology.

Sharifi-Rad, M., Tayeboon, G. S., Sharifi-Rad, J., Iriti, M., Varoni, E. M., & Razazi, S. (2016). Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of Veronica persica phenolic-rich extracts. Cellular and Molecular Biology, 62(6), 80–85. Retrieved from http://cellmolbiol.org/index.php/CMB/article/view/877