Issue
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer
Corresponding Author(s) : M Shariati-Kohbanani
Cellular and Molecular Biology,
Vol. 62 No. 1: Issue 1
Abstract
Ovarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues.
Keywords
Ovarian cancer
BRCA1
Hypermethylation
Micro-RNA.
Shariati-Kohbanani, M., Zare-Bidaki, M., Taghavi, M. M., Taghipour, Z., Shabanizadeh, A., Kennedy, D., Dahim, H., Salahshoor, M. R., Jalili, C., & Kazemi Arababadi, M. (2016). DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer. Cellular and Molecular Biology, 62(1), 16–23. Retrieved from http://cellmolbiol.org/index.php/CMB/article/view/774
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX