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Vol. 61 No. 2: Issue 2

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Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow

H. W Zhang
Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China
X. L Chen
School of Medicine, Shihezi University Department of Immunology Xinjiang China
Z. Y Lin
School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China
J Xia
School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China
J. X Hou
Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China
D Zhou
First Affiliated Hospital, School of Medicine, Shihezi University Medical Laboratory Xinjiang China
Y Xi
Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China
M Zhang
School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China
J Guo
School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China
W Feng
School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China
X. Y Peng
First Affiliated Hospital, School of Medicine, Shihezi University Department of General Surgery Xinjiang China
X. W Wu
First Affiliated Hospital, School of Medicine, Shihezi University Department of General Surgery Xinjiang China

Corresponding Author(s) : X. W Wu

wxwshz@126.com

Cellular and Molecular Biology, Vol. 61 No. 2: Issue 2

Abstract

Endothelial progenitor cells (EPCs) could function as niche cells to promote self-renewal of mesenchymal stem cells (MSCs) in the mouse bone marrow. Cohesion was the basis of the two cells to display their biological functions to each other. In this study, we investigated the mechanism of cohesion between MSCs and EPCs. And demonstrated that fibronectin (FN) in EPCs activated the integrin α5β1 of MSCs and further mediated cell–cell cohesion. Integrin α5β1 and its FN ligand played critical roles not only in single-cell line adhesion, but also in adhesion between stem and niche cells. This novel finding is important to understand the cross-talk between MSCs and their niche cells.

Keywords

Endothelial progenitor cells Mesenchymal stem cells Cohesion Stem cell niche Fibronectin Integrin.
Zhang, H. W., Chen, X. L., Lin, Z. Y., Xia, J., Hou, J. X., Zhou, D., Xi, Y., Zhang, M., Guo, J., Feng, W., Peng, X. Y., & Wu, X. W. (2015). Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow. Cellular and Molecular Biology, 61(2), 26–32. Retrieved from http://cellmolbiol.org/index.php/CMB/article/view/646
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