Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer

Bahare Salehi; Patrick Valere Tsouh Fokou; Lauve Rachel Tchokouaha Yamthe; Brice Tchatat Tali; Charles Oluwaseun Adetunji; Amirhossein Rahavian; Fhatuwani Nixwell Mudau; Natália Martins; Miquel Martorell; Célia F. Rodrigues; William N. Setzer; Mehdi Sharifi-Rad; Ryszard Amarowicz; Javad Sharifi-Rad

doi:10.14715/cmb/2020.66.4.30

Issue

Vol. 66 No. 4: Medicinal plants and natural products

Issue Published : June 23, 2020

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Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer

https://doi.org/10.14715/cmb/2020.66.4.30

Bahare Salehi

Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran

Patrick Valere Tsouh Fokou

Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde I, Ngoa Ekelle, Annex Fac. Sci, P.O. Box 812 Yaounde, Cameroon

Lauve Rachel Tchokouaha Yamthe

Institute for Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé, Cameroon

Brice Tchatat Tali

Antimicrobial Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Messa-Yaoundé, Cameroon

Charles Oluwaseun Adetunji

Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Landmark University, Omu-Aran, Nigeria

Amirhossein Rahavian

Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Fhatuwani Nixwell Mudau

University of South Africa, Department of Agriculture and Animal Health, Private Bag X6, Florida, 1710, South Africa

Natália Martins

Faculty of Medicine, University of Porto, Alameda Prof. Herní¢ni Monteiro, Porto, Portugal

Miquel Martorell

Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile

Célia F. Rodrigues

LEPABE–Dep. of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal

William N. Setzer

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

Mehdi Sharifi-Rad

Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Ryszard Amarowicz

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-748 Olsztyn, Poland

Javad Sharifi-Rad

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Corresponding Author(s) : Javad Sharifi-Rad

javad.sharifirad@gmail.com

Cellular and Molecular Biology, Vol. 66 No. 4: Medicinal plants and natural products
Article Published : June 25, 2020

Abstract

Prostate cancer is an international health problem and represents one of the most encountered malignancies among men. In this complex and heterogeneous disease, androgens and their receptors play a crucial role in both progression and development. Although the search for its effective treatment is still ongoing, among other priorities it requires developing better anticancer agents with greater efficacy and fewer side effects. In this regard, herbal medicines, which have been used in cancer treatment, represent a large source of new and bioactive chemical entities for the development of chemotherapeutic agents, many of them exhibiting favorable side effect and toxicity profiles compared to conventional chemotherapeutic agents. In fact, more than 50% of the current anticancer drugs originate from natural sources. Thus, the present review aims to provide an overview of the past and recent trends in the research, the role of secondary metabolites in urogenital disorders, and phytochemical assays in prostate cancer management.

Keywords

Prostate cancer Medicinal plant Phytotherapy Secondary metabolites Plant extract.

Salehi, B., Tsouh Fokou, P. V., Yamthe, L. R. T., Tali, B. T., Adetunji, C. O., Rahavian, A., Mudau, F. N., Martins, N., Martorell, M., Rodrigues, C. F., Setzer, W. N., Sharifi-Rad, M., Amarowicz, R., & Sharifi-Rad, J. (2020). Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer. Cellular and Molecular Biology, 66(4), 250–263. https://doi.org/10.14715/cmb/2020.66.4.30