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Genotoxicity and cytotoxicity analysis of curcumin and sunset yellow in human lymphocyte culture
Corresponding Author(s) : Anja Haverić
Cellular and Molecular Biology,
Vol. 64 No. 3: Issue 3
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- Clydesdale FM. Color as a factor in food choice. Crit Rev Food Sci Nutr 1993; 33:83-101.
- Mpountoukas P, Pantazaki A, Kostareli E, Christodoulou P, Kareli D, Poliliou S et al. Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine. Food Chemi Toxicol 2010; 48:2934-2944.
- Burrows A. The Palette of Our Palates: A brief history of food coloring and its regulation. Compr Rev Food Sci Food Saf 2009; 8:394-408.
- Schab DW and Trinh NT. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Dev Behav Pediatr 2004; 25:423-434.
- Polí´nio ML and Peres F. Food additive intake and health effects: public health challenges in Brazil. Cad Saude Publica 2009; 25:1653-1666.
- Weiss B. Synthetic Food Colors and Neurobehavioral Hazards: The View from Environmental Health Research. Environ Health Perspect 2012; 120:1–5.
- Uzunısmaıl H, Cengız M, Uzun H, Ozbakir F, Göksel S, Demırdağ F et al. The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn's disease: A pilot study. Turk J Gastroenterol 2012; 23:19-27.
- Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 2007; 1770:578-584.
- Canales-Aguirre AA, Gomez-Pinedo UA, Luquin S, Ramírez-Herrera MA, Mendoza-Magaña ML, Feria-Velasco A. Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain. Nutr Neurosci 2012; 15:62-69.
- Kus E and Eroglu HE. Genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue, colorant food additives, on human blood lymphocytes. Pak J Pharm Sci 2015; 28:227-230.
- Swaroop VR, Dinesh RD, Vijayakumar T. Genotoxicity of Synthetic Food Colorants. Journal of Food Science and Engineering 2011, 1: 128-134.
- Sayed HM, Fouad D, Ataya FS, Hassan NH, Fahmy MA. The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice. Mutat Res 2012; 744:145-153.
- Gomes KMS, Maria Aguiar de Oliveira MVG, Carvalho FRS, Menezes CC, Peron AP. Citotoxicity of food dyes Sunset Yellow (E-110), Bordeaux Red (E-123), and Tatrazine Yellow (E-102) on Allium cepa L. root meristematic cells. Food Sci. Technol (Campinas) 2013; 33(1):218-223
- Dwivedi, K and Kumar G. Genetic Damage Induced by a Food Coloring Dye (Sunset Yellow) on Meristematic Cells of Brassica campestris L. J Environ Public Health 2015; Article ID 319727, http://dx.doi.org/10.1155/2015/319727.
- Izbirak A, Sümer S, Diril N. Mutagenicity testing of some azo dyes used as food additives. Mikrobiyoloji Bulteni 1990; 24:48-56.
- Poul M, Jarry G, Elhkim MO, Poul JM. Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. Food Chemi Toxicol 2009, 47:443-448.
- Kobylewski S and Jacobson MF. Toxicology of food dyes. Int J Occup Med Environ Health 2012, 18:220-246.
- Sebastií N, Soriano JM, Barquinero JF, Villaescusa JI, Almonaci M, Cervera J et al. In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes. Food Chemi Toxicol 2012; 50:3229–3233.
- Mendonça LM, Dos Santos GC, Antonucci GA, Dos Santos AC, Bianchi M de L, Antunes LM. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat Res 2009; 675:29-34.
- Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc 2007; 2:1084-1104.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of curcumin (E 100) as a food additive. EFSA Journal 2010; 8 (9):1679.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. EFSA Journal 2009; 7(11):1330.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific opinion on the reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110). EFSA Journal 2014; 12 (7):3765.
- Hashem MM, Atta AH, Arbid MS, Nada SA, Mouneir SM, Asaad GF. Toxicological Impact of Amaranth, Sunset Yellow and Curcumin as Food Coloring Agents in Albino Rats. J Pak Med Assoc 2011; 1: 43-51.
- Feng J, Cerniglia CE, Chen H. Toxicological significance of azo dye metabolism by human intestinal microbiota. Front Biosci (Elite Ed) 2012; 4(2):568–586.
- Tanaka T. Reproductive and neurobehavioral effects of Allura Red AC administered to mice in the diet. Toxicology 1994; 92:169-177.
- Lucarelli MR, Shirk MB, Julian MW, Crouser ED. Toxicity of Food Drug and Cosmetic Blue No. 1 dye in critically ill patients. Chest 2004; 125:793-795.
- Macioszek VK and Kononowicz AK. The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Cell Mol Biol Lett 2004, 9:107-122.
- Rodricks JV. Food. In: Lippmann M. (ed.), Environmental toxicants: Human exposures and their health effects. Hoboken, John Wiley & Sons Inc. 2009; pp.197-239.
- Cao J, Jiang LP, Liu Y, Yang G, Yao XF, Zhong LF. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells. Toxicon 2007, 49:1219-1222.
- Kumar N, Yadav A, Gulati S, Kanupriya, Aggarwal N, Gupta R. Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism. Journal of Toxicology 2014, Article ID 404236, doi: 10.1155/2014/404236.
- Shafaghati N, Hedayati M, Hosseinimehr SJ. Protective effects of curcumin against genotoxicity induced by 131-iodine in human cultured lymphocyte cell. Pharmacogn Mag 2014; 10(38): 106-110.
- Shimizu N, Itoh N, Utiyama H, Wahl GM. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol 1998; 140:1307-1320.
- Mansilla S, Bataller M, Portugal J. A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells. Biochem Pharmacol 2009; 78:123-132.
References
Clydesdale FM. Color as a factor in food choice. Crit Rev Food Sci Nutr 1993; 33:83-101.
Mpountoukas P, Pantazaki A, Kostareli E, Christodoulou P, Kareli D, Poliliou S et al. Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine. Food Chemi Toxicol 2010; 48:2934-2944.
Burrows A. The Palette of Our Palates: A brief history of food coloring and its regulation. Compr Rev Food Sci Food Saf 2009; 8:394-408.
Schab DW and Trinh NT. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Dev Behav Pediatr 2004; 25:423-434.
Polí´nio ML and Peres F. Food additive intake and health effects: public health challenges in Brazil. Cad Saude Publica 2009; 25:1653-1666.
Weiss B. Synthetic Food Colors and Neurobehavioral Hazards: The View from Environmental Health Research. Environ Health Perspect 2012; 120:1–5.
Uzunısmaıl H, Cengız M, Uzun H, Ozbakir F, Göksel S, Demırdağ F et al. The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn's disease: A pilot study. Turk J Gastroenterol 2012; 23:19-27.
Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 2007; 1770:578-584.
Canales-Aguirre AA, Gomez-Pinedo UA, Luquin S, Ramírez-Herrera MA, Mendoza-Magaña ML, Feria-Velasco A. Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain. Nutr Neurosci 2012; 15:62-69.
Kus E and Eroglu HE. Genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue, colorant food additives, on human blood lymphocytes. Pak J Pharm Sci 2015; 28:227-230.
Swaroop VR, Dinesh RD, Vijayakumar T. Genotoxicity of Synthetic Food Colorants. Journal of Food Science and Engineering 2011, 1: 128-134.
Sayed HM, Fouad D, Ataya FS, Hassan NH, Fahmy MA. The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice. Mutat Res 2012; 744:145-153.
Gomes KMS, Maria Aguiar de Oliveira MVG, Carvalho FRS, Menezes CC, Peron AP. Citotoxicity of food dyes Sunset Yellow (E-110), Bordeaux Red (E-123), and Tatrazine Yellow (E-102) on Allium cepa L. root meristematic cells. Food Sci. Technol (Campinas) 2013; 33(1):218-223
Dwivedi, K and Kumar G. Genetic Damage Induced by a Food Coloring Dye (Sunset Yellow) on Meristematic Cells of Brassica campestris L. J Environ Public Health 2015; Article ID 319727, http://dx.doi.org/10.1155/2015/319727.
Izbirak A, Sümer S, Diril N. Mutagenicity testing of some azo dyes used as food additives. Mikrobiyoloji Bulteni 1990; 24:48-56.
Poul M, Jarry G, Elhkim MO, Poul JM. Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. Food Chemi Toxicol 2009, 47:443-448.
Kobylewski S and Jacobson MF. Toxicology of food dyes. Int J Occup Med Environ Health 2012, 18:220-246.
Sebastií N, Soriano JM, Barquinero JF, Villaescusa JI, Almonaci M, Cervera J et al. In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes. Food Chemi Toxicol 2012; 50:3229–3233.
Mendonça LM, Dos Santos GC, Antonucci GA, Dos Santos AC, Bianchi M de L, Antunes LM. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat Res 2009; 675:29-34.
Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc 2007; 2:1084-1104.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of curcumin (E 100) as a food additive. EFSA Journal 2010; 8 (9):1679.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. EFSA Journal 2009; 7(11):1330.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific opinion on the reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E 110). EFSA Journal 2014; 12 (7):3765.
Hashem MM, Atta AH, Arbid MS, Nada SA, Mouneir SM, Asaad GF. Toxicological Impact of Amaranth, Sunset Yellow and Curcumin as Food Coloring Agents in Albino Rats. J Pak Med Assoc 2011; 1: 43-51.
Feng J, Cerniglia CE, Chen H. Toxicological significance of azo dye metabolism by human intestinal microbiota. Front Biosci (Elite Ed) 2012; 4(2):568–586.
Tanaka T. Reproductive and neurobehavioral effects of Allura Red AC administered to mice in the diet. Toxicology 1994; 92:169-177.
Lucarelli MR, Shirk MB, Julian MW, Crouser ED. Toxicity of Food Drug and Cosmetic Blue No. 1 dye in critically ill patients. Chest 2004; 125:793-795.
Macioszek VK and Kononowicz AK. The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Cell Mol Biol Lett 2004, 9:107-122.
Rodricks JV. Food. In: Lippmann M. (ed.), Environmental toxicants: Human exposures and their health effects. Hoboken, John Wiley & Sons Inc. 2009; pp.197-239.
Cao J, Jiang LP, Liu Y, Yang G, Yao XF, Zhong LF. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells. Toxicon 2007, 49:1219-1222.
Kumar N, Yadav A, Gulati S, Kanupriya, Aggarwal N, Gupta R. Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism. Journal of Toxicology 2014, Article ID 404236, doi: 10.1155/2014/404236.
Shafaghati N, Hedayati M, Hosseinimehr SJ. Protective effects of curcumin against genotoxicity induced by 131-iodine in human cultured lymphocyte cell. Pharmacogn Mag 2014; 10(38): 106-110.
Shimizu N, Itoh N, Utiyama H, Wahl GM. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol 1998; 140:1307-1320.
Mansilla S, Bataller M, Portugal J. A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells. Biochem Pharmacol 2009; 78:123-132.