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Vol. 63 No. 8: Issue 8

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Pleckstrin homology-like domain family B member 1 rs498872 polymorphism and glioma risk in Chinese Han population

https://doi.org/10.14715/cmb/2017.63.8.2
J-W. Zhang
Department of Neurosurgery, Jilin Province Cancer Hospital, Changchun 130012, Jilin, P.R. China
Z-H. Liu
Department of Neurosurgery, Jilin Province Cancer Hospital, Changchun 130012, Jilin, P.R. China
X-H. Lin
Department of Neurosurgery, Jilin Province Cancer Hospital, Changchun 130012, Jilin, P.R. China
Y-P. Du
Department of Neurosurgery, Jilin Province Cancer Hospital, Changchun 130012, Jilin, P.R. China
H-T. Guo
Department of Neurosurgery, Jilin Province Cancer Hospital, Changchun 130012, Jilin, P.R. China

Corresponding Author(s) : H-T. Guo

jiexi86liantu39@163.com

Cellular and Molecular Biology, Vol. 63 No. 8: Issue 8

Abstract

This case-control study aimed to investigate the association between PHLDB1 rs498872 polymorphism and the risk of glioma in a Chinese Han population. A total of 210 patients and 235 controls were enrolled in this study. The CT genotype and TT genotype were significantly associated with the risk of glioma (OR=1.48, 95%CI 1.00-2.19, P=0.05 and OR=2.40, 95%CI 1.06-4.10, P=0.03), respectively. In addition, T allele of PHLDB1 rs498872 polymorphism was significantly associated with an increased risk of glioma (OR=1.58, 95%CI 1.08-2.29, P=0.02). We also found that PHLDB1 rs498872 polymorphism was not associated with histology and tumor grade of glioma. In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma risk in Chinese Han population.

Keywords

PHLDB1 Glioma Polymorphism Association.
Zhang, J.-W., Liu, Z.-H., Lin, X.-H., Du, Y.-P., & Guo, H.-T. (2017). Pleckstrin homology-like domain family B member 1 rs498872 polymorphism and glioma risk in Chinese Han population. Cellular and Molecular Biology, 63(8), 7–9. https://doi.org/10.14715/cmb/2017.63.8.2
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