@article{Chen_Gao_Jin_Wang_2022, title={Preparation of Nano-microbubbles and Curative Effect of 125I Particles for Primary Liver Cancer Guided by Abdominal Interventional Ultrasound: Nano-microbubbles and nanoparticles for Primary Liver Cancer}, volume={68}, url={https://cellmolbiol.org/index.php/CMB/article/view/4317}, DOI={10.14715/cmb/2022.68.3.16}, abstractNote={<p>This study aimed at the preparation of nano-microbubbles (NMBs) and the curative effect of <sup>125</sup>I particles for primary liver cancer guided by abdominal interventional ultrasound. NMBs were prepared by the thin-film hydration method, and NMBs and <sup>125</sup>I particles were connected by biotin to obtain the NMBs-<sup>125</sup>I complex.36 patients with primary liver cancer treated in X Hospital from January to December 2019 were selected. NMBs-<sup>125</sup>I particle implantation was guided by abdominal interventional ultrasound. Computed tomography (CT) or magnetic resonance imaging (MRI) examinations were performed 3 months after treatment, and patients were divided into remission and non-remission groups on account of the results. Contrast-enhanced ultrasound (CEUS) was performed before and 1 month after treatment to analyze and compare the changes in ultrasound parameters. It was shown that there was a good correlation 3 months after treatment between the maximum diameters of the tumor measured by CEUS and CT/MRI, respectively (r=0.856, <em>P</em><0.01). In the remission group, tRTpre and tTTPprc 1 month after treatment were higher than those before treatment, but tPIpre and tSERmax.pre were lower than those before treatment. In the non-remission group, tRTpre and tTTPprc 1 month after treatment were lower than those before treatment, but tPIpre and tSERmax.pre were higher than those before treatment. Therefore, CEUS had a higher value on the efficacy of the NMBs-<sup>125</sup>I particle implantation for primary liver cancer.</p>}, number={3}, journal={Cellular and Molecular Biology}, author={Chen, Yan and Gao, Shan and Jin, Yuan and Wang, Xiaofeng}, year={2022}, month={Mar.}, pages={131–139} }