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  3. Vol. 68 No. 3: New findings of cellular, molecular, and medical biology using nanotechnology
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Vol. 68 No. 3: New findings of cellular, molecular, and medical biology using nanotechnology

Issue Published : August 9, 2022

Preparation of Nano-microbubbles and Curative Effect of 125I Particles for Primary Liver Cancer Guided by Abdominal Interventional Ultrasound

Nano-microbubbles and nanoparticles for Primary Liver Cancer
https://doi.org/10.14715/cmb/2022.68.3.16
Yan Chen
Department of B-ultrasound Room of Physical Diagnosis, Daqing Longnan Hospital (The Fifth Affiliated Hospital of Qiqihar Medical College), Daqing, 163453, China
Shan Gao
Department of B-ultrasound Room of Physical Diagnosis, Daqing Longnan Hospital (The Fifth Affiliated Hospital of Qiqihar Medical College), Daqing, 163453, China
Yuan Jin
Department of B-ultrasound Room of Physical Diagnosis, Daqing Longnan Hospital (The Fifth Affiliated Hospital of Qiqihar Medical College), Daqing, 163453, China
Xiaofeng Wang
Department of B-ultrasound Room of Physical Diagnosis, Daqing Longnan Hospital (The Fifth Affiliated Hospital of Qiqihar Medical College), Daqing, 163453, China

Corresponding Author(s) : Xiaofeng Wang

lujiaonuo4924@163.com

Cellular and Molecular Biology, Vol. 68 No. 3: New findings of cellular, molecular, and medical biology using nanotechnology
Article Published : March 31, 2022

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Abstract

This study aimed at the preparation of nano-microbubbles (NMBs) and the curative effect of 125I particles for primary liver cancer guided by abdominal interventional ultrasound. NMBs were prepared by the thin-film hydration method, and NMBs and 125I particles were connected by biotin to obtain the NMBs-125I complex.36 patients with primary liver cancer treated in X Hospital from January to December 2019 were selected. NMBs-125I particle implantation was guided by abdominal interventional ultrasound. Computed tomography (CT) or magnetic resonance imaging (MRI) examinations were performed 3 months after treatment, and patients were divided into remission and non-remission groups on account of the results. Contrast-enhanced ultrasound (CEUS) was performed before and 1 month after treatment to analyze and compare the changes in ultrasound parameters. It was shown that there was a good correlation 3 months after treatment between the maximum diameters of the tumor measured by CEUS and CT/MRI, respectively (r=0.856, P<0.01). In the remission group, tRTpre and tTTPprc 1 month after treatment were higher than those before treatment, but tPIpre and tSERmax.pre were lower than those before treatment. In the non-remission group, tRTpre and tTTPprc 1 month after treatment were lower than those before treatment, but tPIpre and tSERmax.pre were higher than those before treatment. Therefore, CEUS had a higher value on the efficacy of the NMBs-125I particle implantation for primary liver cancer.

Keywords

nano-microbubbles primary liver cancer contrast-enhanced ultrasound 125I particles interventional therapy abdominal interventional ultrasound
Chen, Y., Gao, S., Jin, Y., & Wang, X. (2022). Preparation of Nano-microbubbles and Curative Effect of 125I Particles for Primary Liver Cancer Guided by Abdominal Interventional Ultrasound: Nano-microbubbles and nanoparticles for Primary Liver Cancer. Cellular and Molecular Biology, 68(3), 131–139. https://doi.org/10.14715/cmb/2022.68.3.16
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