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Vol. 66 No. 7: Issue 7

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Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats

https://doi.org/10.14715/cmb/2020.66.7.18
Nadir Mustafa Nanakali
Department of Biology, College of Education, Salahaddin University-Erbil, Iraq

Corresponding Author(s) : Nadir Mustafa Nanakali

nadir.nanakali@su.edu.krd

Cellular and Molecular Biology, Vol. 66 No. 7: Issue 7

Abstract

The purpose of this study was to evaluate the prophylactic effects of quercetin (QUE) against oxidative damages and histological changes induced by 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin (TCDD) in rat heart. For this purpose, 20 adult male Wistar rats were divided into four groups as fellow control group, TCDD group (10µg/kg BW/day by gavage daily for 60 consecutive days), QUE group (30 mg/kg BW/day) and TCDD + QUEgroup. The oxidative biomarkers of heart tissue and the levels of cTnI and lipid profile in serum were measured. Our results showed that the cTnI serum level and the heart lipid peroxidation significantly increased and the heart level of antioxidant profile significantly decreased in the TCDD group compared to control and QUEgroups. While pretreatment with QUEcould significantly improved these factors in serum and heart tissue in animals that consumed TCDD. It can be concluded that QUEat doses of 30 mg/kg/day could alleviate heart oxidative damage and histological changes induced by TCDD.

Keywords

Quercetin 1 2 3 4-Tetrachlorodibenzo-P-Dioxin (TCDD) Oxidative stress Heart.
Nanakali, N. M. (2020). Quercetin may repair the impaired oxidant-antioxidant balance in 1, 2, 3, 4-tetrachlorodibenzo-p-dioxin induced cardiac injury in male rats. Cellular and Molecular Biology, 66(7), 118–123. https://doi.org/10.14715/cmb/2020.66.7.18
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References
  1. World Health, O., Dioxins and their effects on human health, in Dioxins and their effects on human health. 1999.
  2. Abdulkareem, S.M. and N.M. Nanakali, Ameliorating Potential of Quercetin on Liver Function, Genotoxicity and Oxidative Damage Induced by 2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin in Liver of Male Rats. Pakistan Journal of Zoology, 2020. 52(2).
  3. Abdulkareem, S.M. and N.M. Nanakali, Quercetin Reduces Oxidative Stress Damage To Reproductive Profile Induced By 2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin In Male Albino Rats (Rattus Norvegicus L.). Applied Ecology And Environmental Research, 2019. 17(6): p. 13185-13197.
  4. Dhanabalan, S. and P.P. Mathur, Low dose of 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin induces testicular oxidative stress in adult rats under the influence of corticosterone. Experimental and Toxicologic Pathology, 2009. 61(5): p. 415-423.
  5. Czepiel, J., et al., The effect of TCDD dioxin on the rat liver in biochemical and histological assessment. Folia Biologica, 2009. 58(1-2): p. 85-90.
  6. Biswas, G., et al., Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling. Proceedings of the National Academy of Sciences, 2008. 105(1): p. 186-191.
  7. Patterson, R.M., R. Stachlewitz, and D. Germolec, Induction of apoptosis by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin following endotoxin exposure. Toxicology and applied pharmacology, 2003. 190(2): p. 120-134.
  8. Dalton, T.P., et al., Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovascular toxicology, 2001. 1(4): p. 285-298.
  9. Ciftci, O., O.M. Disli, and N. Timurkaan, Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats. Toxicology and industrial health, 2013. 29(9): p. 806-811.
  10. Mohsenzadeh, M.S., B.R. Zanjani, and G. Karimi, Mechanisms of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced cardiovascular toxicity: An overview. Chemico-biological interactions, 2018. 282: p. 1-6.
  11. Xie, A., N.J. Walker, and D. Wang, Dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-doxin) enhances triggered afterdepolarizations in rat ventricular myocytes. Cardiovascular toxicology, 2006. 6(2): p. 99-110.
  12. Dietrich, C., Antioxidant functions of the aryl hydrocarbon receptor. Stem cells international, 2016. 2016.
  13. Reichard, J.F., et al., Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-Response, 2005. 3(3): p. dose-response.
  14. Dhalla, N.S., R.M. Temsah, and T. Netticadan, Role of oxidative stress in cardiovascular diseases. Journal of hypertension, 2000. 18(6): p. 655-673.
  15. Nimrouzi, M., et al., Oil and extract of safflower seed improve fructose induced metabolic syndrome through modulating the homeostasis of trace elements, TNF-α, and fatty acids metabolism. Journal of Ethnopharmacology, 2020: p. 112721.
  16. Jelodar, G., et al., Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin"induced diabetic rats. Physiological Reports, 2020. 8(1): p. e14348.
  17. Ostovar, M., et al., Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy. Journal of Integrative Medicine, 2020. 18(1): p. 59-67.
  18. Kumar, S. and A.K. Pandey, Chemistry and biological activities of flavonoids: an overview. The Scientific World Journal, 2013. 2013.
  19. Litvinov, D., H. Mahini, and M. Garelnabi, Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. North American Journal of medical sciences, 2012. 4(11): p. 523.
  20. Erden Inal, M., A. Kahraman, and T. Köken, Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clinical and experimental dermatology, 2001. 26(6): p. 536-539.
  21. Ciftci, O., N. Vardi, and I. Ozdemir, Effects of quercetin and chrysin on 2, 3, 7, 8"tetrachlorodibenzo"p"dioxin induced hepatotoxicity in rats. Environmental Toxicology, 2013. 28(3): p. 146-154.
  22. Ciftci, O., S. Tanyildizi, and A. Godekmerdan, Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD). Immunopharmacology and Immunotoxicology, 2010. 32(1): p. 99-104.
  23. Le Magueresse-Battistoni, B., et al., Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders. World journal of biological chemistry, 2017. 8(2): p. 108.
  24. Kopf, P.G., J.K. Huwe, and M.K. Walker, Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Cardiovasc Toxicol, 2008. 8(4): p. 181-93.
  25. Lund, A.K., et al., Endothelin-1–Mediated increase in reactive oxygen species and NADPH oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice. Toxicological Sciences, 2005. 88(1): p. 265-273.
  26. El-Demerdash, F.M., et al., Xenobiotics, oxidative stress, and antioxidants. Oxidative medicine and cellular longevity, 2018. 2018.
  27. Tamaki, H., et al., Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology, 2005. 216(2-3): p. 224-231.
  28. Wu, T.-T., et al., Atherogenic index of plasma (AIP): a novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids in health and disease, 2018. 17(1): p. 197.
  29. Yousef, M.I., et al., Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food and Chemical Toxicology, 2010. 48(11): p. 3246-3261.
  30. Vicente-Sánchez, C., et al., Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity. Food and chemical toxicology, 2008. 46(6): p. 2279-2287.
  31. Akbari, A., G. Jelodar, and S. Nazifi, The proposed mechanisms of radio frequency waves (RFWs) on nervous system functions impairment. Comparative Clinical Pathology, 2016. 25(6): p. 1289-1301.
  32. Akbari, A., et al., Oxidative Stress as the Underlying Biomechanism of Detrimental Outcomes of Ionizing and Non-Ionizing Radiation on Human Health: Antioxidant Protective Strategies. Zahedan Journal of Research in Medical Sciences, 2019. 21(4): p. DIO 10.5812/zjrms.85655.
  33. Shin, S., et al., NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and cellular biology, 2007. 27(20): p. 7188-7197.
  34. Ma, Q., Role of nrf2 in oxidative stress and toxicity. Annual review of pharmacology and toxicology, 2013. 53: p. 401-426.
  35. Elshater AE, Salman M, Mohamed AS. Effect of Fullerene C60 (NPs) on Cyclophosphamide-Induced Hepato and Cardiac Toxicity in Male Albino Rats. Egypt Acad J Biol Sci C Physiol Mol Biol 2017 Jun 1;9(1):27-36.
  36. Kholoussi N, Taalat RM. Determination OF Apolipoprotein (E) Genotypes By PCR And Relation To Plasma Lipid In Coronary Heart Disease Patients. Egypt Acad J Biol Sci C Physiol Mol Biol 2016 Dec 1;8(1):23-9.
  37. Shokr ES. Effect of exam stress on heart rate variability parameters in healthy students. Egypt Acad J Biol Sci C Physiol Mol Biol 2015 Sep 1;7(1):75-81.
  38. El-Sayed MF, Ibrahim AS, Okil HA, Abdel-karim DA. The role of sarcoplasmic reticulum and sarcolemma in the regulation of cardiac contractility at different times and higher extracellur potassium in the cardiac muscle of catfish and toad. Egypt Acad J Biol Sci C Physiol Mol Biol 2010 Dec 1;2(2):99-113.
  39. Omidvar F, Bouzarjomehri F, Falahati F, Zare M. Patient radiation dosimetry during interventional cardiac procedures. Int J Radiat Res. 2020; 18 (3) :511-519.
  40. Goldoost B, Jabbari N, Esnaashari O, Mostafanezhad K. Evaluating the effects of esophageal and breast cancer radiotherapy on the cardiac function and determining the relationship between the dosimetric parameters and ejection fraction changes. Int J Radiat Res. 2019; 17 (2) :237-244.
  41. Farzanefar S, Mirzabeigi A, Abbasi M. The incidental lung lesion: effect of cardiac stress on the MIBI uptake in the lung mass. Int J Radiat Res. 2016; 14 (1) :77-79.
  42. Sardari Kermani M, Razi F, Esmati E. Cardiac angiosarcoma Report of a case. Int J Radiat Res. 2005; 2 (4) :215-218.
  43. Akhtar G, Jaskani MJ, Sajjad Y, Akram A. Effect of Antioxidants, Amino Acids and Plant Growth Regulators on in vitro Propagation of Rosa centifolia. Iran J Biotechnol. Mar 2016; 14(1): 51-55.
  44. Shakibaie M, Adeli-Sardou M, Mohammadi-Khorsand T, ZeydabadiNejad M, Amirafzali E, Amirpour-Rostami S, Ameri A, Forootanfar H. Antimicrobial and Antioxidant Activity of the Biologically Synthesized Tellurium Nanorods; A Preliminary In vitro Study. Iran J Biotechnol. 2017; 15(4): 268-276.
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