The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats
Corresponding Author(s) : N. J. Siddiqi
nikhat@ksu.edu.sa
Cellular and Molecular Biology,
Vol. 63 No. 6: International conference on translational biotechnology- Biosangam
Abstract
Acrylamide (ACR) is a neurotoxicant, reproductive toxicant, and carcinogen in animal species. It is used in many industries and has been found to form naturally in foods cooked at high temperatures. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant whose therapeutic effect has been related to its antioxidant activity. This study was carried out to study the protective effect of alpha lipoic acid on acrylamide induced perturbations in rat liver. Four groups of rats were studied viz., control rats, acrylamide treated rats, alpha lipoic acid treated rats, and alpha lipoic acid plus acrylamide treated rats. ACR and ALA treatment alone and together caused a significant increase in hepatic reduced glutathione content while a decrease in hepatic ascorbic content was observed when compared to control group. ALA pretreatment of acrylamide exposed rats caused no a significant alteration in superoxide dismutase activity but resulted in a tendency towards restoration of glutathione peroxidase and catalase activity to near normal levels. Gel electrophoresis showed fragmentation of DNA in the treated groups. The dose of ALA used in the present study afforded partial restoration of oxidative indices altered by ACR in rat liver.
Keywords
Acrylamide
Lipoic acid
Oxidative stress
Antioxidants
Rat
Liver.
Al-Qahtani, F. A., Arafah, M., Sharma, B., & Siddiqi, N. J. (2017). Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats. Cellular and Molecular Biology, 63(6), 1–6. https://doi.org/10.14715/cmb/2017.63.6.1
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
